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Fig. 29 | Malaria Journal

Fig. 29

From: The past, present and future of anti-malarial medicines

Fig. 29

Key stages in the hit to lead pathway of KAE609. Resolution of the initial racemic hit (K′1) gave the significantly more potent stereoisomer (K′2). Reducing the ring size further increased the potency and final halogenation of the indole ring led to the optimized compound KAE609

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