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Table 1 Baseline characteristics of artesunate-amodiaquine fixed-dose combination treated Ghanaian patients with uncomplicated P. falciparum malaria

From: Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

 

Age category (years)

Total

 < 1

1–4

 ≥ 5

N (%)

308 (100)

13 (4.2)

176 (57.1)

119 (38.6)

Sex, Female, n (%)

161 (52.3)

8 (61.5)

92 (52.3)

61 (51.3)

Underweightb (WAZ < − 2.00), n/N (%)

28/190 (14.7)a

0 (0.0)

26 (13.6)

2

Axillary temperature (oC), mean (SD)

38.0 (1.1)

38.3 (0.8)

38.1 (1.1)

37.7 (1.2)

Haemoglobin (g/dL), mean (SD)

10.0 (1.9)

8.5 (1.3)

9.5 (1.8)

11.0 (1.8)

Moderate- to- severe anaemia patients (Hb < 8.0 g/dL), n (%)

47 (15.3)

5 (38.5)

37 (21.0)

5 (4.2)

Severe anaemia (Hb < 6.0 g/dL), n (%)

4 (1.3)

0 (0)

4 (2.3)

0(0)

Geometric mean parasite density, (95% CI)

27,594 (23,737–32,079)

15,879 (5871–42,945)

34,921 (28,916–42,172)

20,692 (16,184–26,455)

Parasite density ≥ 100,000, n (%)

47 (15.3)

3 (23.1)

32 (18.2)

12 (10.1)

Gametocyte Prevalence, n (%)

9 (2.9)

1 (7.7)

6 (3.4)

2 (1.7)

Total Dose (mg/ kg), median (IQR); range

31.2 (26.1–38.9) 7.6–52.6

25.3 (23.8–25.3) 13.4–31.15

33.8 (27.0–39.7) 14.5–45.0

33.8 (25.3–38.6) 7.2–52.6

D0 AQ concentration > LLOQ, n (%)

64 (20.8)

0(0)

45 (25.6)

19 (16.0)

  1. N = Sample population, n = number of patients in category, WAZ = weight-for-age Z-score, sd = standard deviation, Hb = haemoglobin concentration, CI = confidence interval, mg/kg = milligram per kilogram, IQR = interquartile range, D0 = Day 0 pre-dose, AQ = amodiaquine, BLQ = below the limit of quantification
  2. a Two patients aged 5 years
  3. bWAZ score only calculated for children ≤ 5 years; 2/13 (15.4%) children aged 5 years had WAZ score < − 2.00