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Table 3 The association between CYP2D6 genotypes and the relapse of vivax malaria

From: The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China

Alleles

Total

No (n1 = 238, F/%)

Case groups

x2

P

SR group

No. (n1 = 88, F/%)

NR group

No. (n1 = 150, F/%)

a. Alleles

*1

47 (19.7)

10 (11.4)

37 (24.7)

6.193

0.013b (S)

*2

17 (7.1)

14 (15.9)

3 (2.0)

16.177

0.000b (S)

*4

3 (1.3)

3 (3.4)

0

2.802

0.094b (NS)

*10

108 (45.4)

34 (38.6)

74 (49.3)

2.560

0.110b (NS)

*39

28 (11.8)

15 (17.0)

13 (8.7)

3.751

0.053b (NS)

*sa

20 (8.4)

5 (5.7)

15 (10.0)

1.344

0.246b (NS)

Othera

15 (6.3)

7 (8.0)

8 (5.3)

1.766

0.184b (NS)

Genotypes

Case groups

ORc

95%CI

P

SR group

No. (n2 = 44, F/%)

NR group

No. (n2 = 75, F/%)

Upper limit

Low limit

b. Genotypes

*1/*1

1 (2.3)

11 (14.7)

0.135

0.017

1.087

0.064b (NS)

*2/*2

4 (9.1)

1 (1.3)

7.400

0.800

68.463

0.118b (NS)

*1/*2

4 (9.1)

1 (1.3)

7.400

0.800

68.463

0.118b (NS)

*1/*10

2 (4.5)

12 (16.0)

0.250

0.050

1.174

0.115b (NS)

*10/*10

12 (27.3)

24 (32.0)

0.797

0.350

1.873

0.588b (NS)

*10/*sa

1 (2.3)

1 (1.3)

1.721

0.105

28.220

1.000b (NS)

*10/*39

5 (11.4)

3 (4.0)

3.077

0.698

13.563

0.242b (NS)

*39/*39

2 (4.5)

1 (1.3)

3.524

0.310

40.032

0.636b (NS)

*39/*sa

2 (4.5)

7 (9.3)

0.463

0.092

2.332

0.552b (NS)

  1. n1 number of chromosomes, n2 number of cases, F Frequency
  2. Other: *m, *n, *o, *p, *q,*r,*t, *u, *v, *w and *x; a They could not meet the allele inclusion criteria provided by the Allele Nomenclature Committee [32]; bChi-square test; NS: not significant (P > 0.05); cThe OR value of genotypes were calculated by comparing to the relapse rate of P. vivax; S: significant (P < 0.05); NS: not significant (P > 0.05)