Fig. 8

Left: Temporal profiles of P. vivax recurrence at different levels of chloroquine resistance. At high levels of resistance (as seen currently in Indonesia and Papua New Guinea) early recrudescence dominates (red dashed line). At lower levels of resistance (as seen currently on the Thailand–Myanmar border) the relapses appear earlier than previously, and a few appear within 28 days (orange dashed line). In fully sensitive infections no relapses appear within 4 weeks, and very few occur before 6 weeks (green dashed line). Right: The effect of chloroquine dose (and thus exposure) on the time to P. vivax recurrence; from Commons et al. [52]