Variable | Hyperemia (n = 57) | IPH (n = 35) | Low flow (n = 50) | MO (n = 14) | Vasospasm (n = 11) | Normal (n = 7) | p |
---|---|---|---|---|---|---|---|
Age (months), mean (SD) | 55 (31) | 58 (37) | 59 (37) | 56 (25) | 67 (32) | 72 (29) | 0.71 |
Temperature (°C), median [IQR] | 38.5 [37.7, 39.1] | 38.5 [37.8, 39.4] | 38.0 [37.1, 39.2] | 38.5 [37.6, 39.3] | 37.8 [37.6, 38.5] | 38.5 [38.0, 39.0] | 0.25 |
Heart rate (beats/min), median [IQR] | 141 [127, 152] | 143 [128, 158] | 142 [123, 161] | 140 [124, 158] | 140 [136, 146] | 133 [130, 136] | 0.97 |
RR (breaths/min), median [IQR] | 32.0 [26.0, 39.0] | 36.0 [28.0, 43.0] | 36.0 [32.0, 42.8] | 34.5 [32.2, 39.5] | 36.0 [32.5, 44.5] | 40.0 [39.5, 45.0] | 0.07 |
Oxygen saturation (%), median [IQR] | 97.0 [95.0, 98.0] | 97.0 [96.0, 99.0] | 97.0 [95.0, 98.0] | 98.0 [96.2, 98.0] | 98.0 [97.0, 99.0] | 96.0 [96.0, 97.5] | 0.21 |
MBP (mmHg), median [IQR] | 78.0 [71.0, 84.0] | 78.0 [72.5, 86.5] | 83.5 [73.2, 90.0] | 73.0 [65.8, 80.5] | 75.0 [68.5, 86.5] | 74.0 [71.0, 79.0] | 0.21 |
Pulse pressure (mmHg), median [IQR] | 43.0 [39.0, 55.0] | 38.0 [35.0, 44.0] | 37.5 [33.0, 44.8] | 35.5 [34.0, 43.2] | 38.0 [35.0, 42.0] | 33.0 [33.0, 35.5] | 0.003 |
Stroke volume index (ml/m2), median [IQR] | 39.0 [34.2, 44.8] | 39.0 [33.5, 43.5] | 32.0 [28.5, 41.0] | 43.0 [38.2, 50.8] | 42.0 [38.2, 46.2] | 38.0 [35.0, 42.5] | 0.08 |
Cardiac index (l/min/m2), median [IQR] | 5.30 [4.90, 5.88] | 5.40 [4.55, 5.90] | 4.40 [3.70, 5.00] | 6.00 [5.18, 6.60] | 5.55 [5.20, 6.60] | 4.20 [4.00, 5.05] | < 0.001 |
SVRI (d.s.cm−5m2), median [IQR] | 1270 [1070, 1392] | 1306 [1198, 1580] | 1552 [1197, 1961] | 962 [919, 991] | 1187 [903, 1334] | 1378 [1294, 1660] | 0.003 |
Packed Cell Volume (%),median [IQR] | 26.0 [20.0, 29.0] | 26.0 [21.5, 30.0] | 27.5 [22.2, 32.8] | 27.5 [24.2, 30.8] | 23.0 [19.5, 25.0] | 27.0 [25.0, 28.0] | 0.08 |
Glucose (mmol/L), median [IQR] | 5.30 [4.40, 6.20] | 5.90 [4.60, 6.60] | 5.65 [4.40, 6.90] | 5.30 [4.38, 8.85] | 5.80 [5.40, 6.60] | 5.70 [5.15, 6.50] | 0.74 |
Lactate (mmol/L), median [IQR] | 4.30 [2.60, 6.80] | 3.00 [2.10, 5.30] | 4.05 [2.02, 8.60] | 4.15 [2.10, 6.95] | 5.00 [2.75, 8.35] | 4.00 [3.00, 4.70] | 0.87 |
Parasites/microliter blood, median [IQR] | 455,000 [27,000, 975,000] | 346,000 [108,000, 1,499,000] | 464,000 [180,000 1,280,000] | 126,000 [67,000, 459,000] | 116,000 [62,000, 237,000] | 246,000 [174,000, 815,000] | 0.52 |
PfHRP2 (ng/mL), median [IQR] | 396 [111,1021] | 913 [46, 1270] | 333 [122, 874] | 123 [13, 282] | 330 [44,687] | 807 [545, 996] | .006 |
pH, median [IQR] | 7.42 [7.36, 7.46] | 7.42 [7.36, 7.45] | 7.41 [7.38, 7.46] | 7.44 [7.36, 7.48] | 7.38 [7.35, 7.50] | 7.41 [7.38, 7.44] | 0.99 |
CO2 (mmHg), median [IQR] | 29.0 [23.0, 36.0] | 28.5 [24.8, 34.0] | 27.5 [24.0, 31.0] | 27.0 [24.5, 30.5] | 22.5 [18.0, 26.5] | 26.0 [25.5, 34.5] | 0.53 |
Base excess, median [IQR] | 2.10 [-3.00, 6.50] | 0.80 [-6.50, 6.00] | 0.10 [-6.00, 5.00] | 3.30 [2.70, 7.82] | 3.00 [0.50, 20.2] | 5.00 [1.50, 6.00] | 0.22 |
Sodium (mEq/L), median [IQR] | 139 [137, 143] | 139 [136, 144] | 140 [135, 143] | 136 [134, 139] | 138 [134, 140] | 141 [137, 146] | 0.29 |
Bicarbonate (mmol/L), median [IQR] | 17.0 [13.0, 20.2] | 17.0 [15.0, 19.0] | 18.0 [13.5, 20.5] | 17.8 [12.2, 20.0] | 18.0 [13.5, 21.5] | 18.5 [17.8, 20.0] | 0.93 |
Retinopathy positive, n (%) | 37 (65) | 21 (60) | 36 (72) | 10 (71.4) | 6 (54.5) | 5 (71.4) | 0.80 |
Blantyre coma score, n (%) | 0.05 | ||||||
0 | 7 (13) | 5 (14) | 8 (16) | 4 (29) | 2 (18) | 0 (0) | |
1 | 15 (26) | 14 (40) | 26 (52) | 3 (21) | 3 (27) | 3 (43) | |
2 | 35 (61) | 16 (46) | 16 (32) | 7 (50) | 6 (55) | 4 (57) | |
Seizures on EEG, n (%) | 6 (11) | 1 (3) | 4 (8) | 3 (21) | 2 (18) | 0 (0) | 0.38 |
Papilloedema present, n (%) | 3 (5) | 1 (3) | 3 (6) | 2 (14) | 1 (9) | 0 (0) | 0.37 |
Opening pressure (cm H20), median [IQR] | 15.5 [12.0, 21.5] | 16.0 [13.5, 21.5] | 17.0 [12.0, 22.0] | 18.0 [14.0, 19.0] | 21.5 [12.8, 26.0] | 19.0 [12.0, 23.5] | 0.83 |
ONSD (mm), median [IQR] | 0.48 [0.44, 0.53] | 0.48 [0.44, 0.50] | 0.48 [0.45, 0.50] | 0.49 [0.45, 0.53] | 0.45 [0.42, 0.48] | 0.46 [0.44, 0.47] | 0.59 |
Time to coma resolution (hrs), median [IQR] | 26.0 [20.0, 61.5] | 44.0 [24.0, 79.5] | 52.0 [25.5, 90.5] | 40.0 [31.0, 51.0] | 47.0 [19.5, 114] | 36.0 [27.0, 36.0] | 0.23 |
Brain volume score, n (%)* | n = 34 | n = 17 | n = 24 | n = 10 | n = 7 | n = 2 | 0.95 |
3 | 3 (9) | 1 (6) | 1 (4) | 1 (10) | 1 (14) | 0 (0) | |
4 | 3 (9) | 1 (6) | 3 (13) | 1 (10) | 0 (0) | 0 (0) | |
5 | 13 (38) | 6 (35) | 8 (33) | 3 (30) | 3 (43) | 0 (0) | |
6 | 9 (26) | 4 (24) | 5 (21) | 2 (20) | 2 (29) | 2 (100) | |
7 | 5 (15) | 5 (29) | 5 (21) | 2 (20) | 1 (14) | 0 (0) | |
8 | 1 (3) | 0 (0) | 2 (8) | 1 (10) | 0 (0) | 0 (0) | |
Autoregulation (THRR), median [IQR] | 1.05 [1.01, 1.12] | 1.11 [1.07, 1.19] | 1.10 [1.03, 1.20] | 1.09 [1.07, 1.13] | 1.04 [1.01, 1.06] | 1.20 [1.14;1.27] | 0.13 |
Outcome, n (%) | < .001 | ||||||
Good | |||||||
PCPC 1 -2 (normal, mild disability) | 44 (77) | 31 (89) | 21 (42) | 9 (64) | 6 (55) | 7 (100) | |
Poor | |||||||
PCPC 3–5 (moderate to severe disability) | 8 (14) | 3(9) | 14 (28) | 3 (21) | 5 (45) | 0 (0) | |
PCPC 6 (died) | 5 (9) | 1 (2) | 15 (30) | 2 (15) | 0 (0) | 0 (0) |