Figure 1

Survival and parasitemia evolution after MA treatment. ICR mice were infected with 10⁷ P. yoelii 17XL infected RBC and treated 2 hours post-infection with maslinic acid 40 mg Kg^-1 day^-1, (0.8 mg per mouse per day) for 4 days, starting 2 hours after infection. A) Survival of treated mice (solid line, n = 10) and untreated control (dashed line, n = 10). Results are presented as the survival percent of one representative experiment. P = 0.009 (statistically significant difference between the treated group and the control); B) Parasitemia dynamics in MA-treated (n = 10) and non-treated (n = 10) groups. Black circles: Survivors from MA-treated group; white circles: survivors from non-treated group, and triangles: non-surviving mice. †: 100% mortality. Results are presented as mean+SD of one representative experiment. Day 7, P < 0.001 survivors (treated or untreated) vs non-survivors.