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  1. Content type: Research

    House improvement and environmental management can significantly improve malaria transmission control in endemic communities. This study assessed the influence of physical characteristics of houses and surroun...

    Authors: Emmanuel W. Kaindoa, Marceline Finda, Jepchirchir Kiplagat, Gustav Mkandawile, Anna Nyoni, Maureen Coetzee and Fredros O. Okumu

    Citation: Malaria Journal 2018 17:298

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  2. Content type: Research

    Much of the extensive research regarding transmission of malaria is underpinned by mathematical modelling. Compartmental models, which focus on interactions and transitions between population strata, have been...

    Authors: Neal R. Smith, James M. Trauer, Manoj Gambhir, Jack S. Richards, Richard J. Maude, Jonathan M. Keith and Jennifer A. Flegg

    Citation: Malaria Journal 2018 17:299

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  3. Content type: Research

    Vivax malaria is a leading public health concern worldwide. Due to the high prevalence of Duffy-negative blood group population, Plasmodium vivax in Africa historically is less attributable and remains a neglecte...

    Authors: Mohammad Rafiul Hoque, Mohammed Mohieldien Abbas Elfaki, Md Atique Ahmed, Seong-Kyun Lee, Fauzi Muh, Musab M. Ali Albsheer, Muzamil Mahdi Abdel Hamid and Eun-Taek Han

    Citation: Malaria Journal 2018 17:297

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  4. Content type: Case study

    Vivax malaria reemerged along the Demilitarized Zone (DMZ), Republic of Korea (ROK), in 1993. While it was hypothesized that vivax malaria would spread throughout the peninsula, nearly all cases were due to ex...

    Authors: Jae Hyoung Im, Kyungmin Huh, Chang-Gyo Yoon, Hyeongtaek Woo, Jin-Soo Lee, Moon-Hyun Chung, Terry A. Klein and Jaehun Jung

    Citation: Malaria Journal 2018 17:295

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  5. Content type: Research

    Malaria continues to be a global burden as the efficacy of most commercial anti-malarial drugs has been compromised by the evolution of parasite resistance. With the urgent need created for the development of ...

    Authors: Zoxolo N. Nyaba, Pretty Murambiwa, Andy R. Opoku, Samson Mukaratirwa, Francis O. Shode and Mthokozisi B. C. Simelane

    Citation: Malaria Journal 2018 17:296

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  6. Content type: Research

    Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabo...

    Authors: Bharathi Avula, Babu L. Tekwani, Narayan D. Chaurasiya, Pius Fasinu, N. P. Dhammika Nanayakkara, H. M. T. Bhandara Herath, Yan-Hong Wang, Ji-Yeong Bae, Shabana I. Khan, Mahmoud A. Elsohly, James D. McChesney, Peter A. Zimmerman, Ikhlas A. Khan and Larry A. Walker

    Citation: Malaria Journal 2018 17:294

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  7. Content type: Research

    Malaria is an important public health problem in Tanzania. The latest national malaria data suggests rebound of the disease in the country. Anopheles arabiensis, a mosquito species renowned for its resilience aga...

    Authors: Rashid A. Khatib, Prosper P. Chaki, Duo-Quan Wang, Yeromin P. Mlacha, Michael G. Mihayo, Tegemeo Gavana, Ning Xiao, Xiao-Nong Zhou and Salim Abdullah

    Citation: Malaria Journal 2018 17:292

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  8. Content type: Research

    To understand more about changes to the molecular components that occur when host endothelium interacts with Plasmodium falciparum-infected erythrocytes, a combined technique of protein separation (1D Blue-Native...

    Authors: Yang Wu, Simon C. Wagstaff, Saeed A. Al-Harthi and Alister G. Craig

    Citation: Malaria Journal 2018 17:293

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  9. Content type: Research

    In Ethiopia, malaria has declined in the last decade; only a small number of cases have been reported, primarily from hotspots. The contribution of house proximity to water bodies and the role of migration in ...

    Authors: Asmamaw Malede, Kassahun Alemu, Mulugeta Aemero, Sirak Robele and Helmut Kloos

    Citation: Malaria Journal 2018 17:290

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  10. Content type: Research

    The extensive research on community members’ willingness to support malaria interventions ignores the role of psychosocial determinants. This study assesses the impact of individuals’ sense of community (perce...

    Authors: D. Yaw Atiglo, Reuben Tete Larbi, Mawuli Komla Kushitor, Adriana A. E. Biney, Paapa Yaw Asante, Naa Dodua Dodoo and F. Nii-Amoo Dodoo

    Citation: Malaria Journal 2018 17:289

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  11. Content type: Research

    Rodent malaria parasites where the gene encoding circumsporozoite protein (CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium falciparum or Plasmodium vivax, are used as pre-clinic...

    Authors: Catherin Marin-Mogollon, Fiona J. A. van Pul, Shinya Miyazaki, Takashi Imai, Jai Ramesar, Ahmed M. Salman, Beatrice M. F. Winkel, Ahmad Syibli Othman, Hans Kroeze, Severine Chevalley-Maurel, Arturo Reyes-Sandoval, Meta Roestenberg, Blandine Franke-Fayard, Chris J. Janse and Shahid M. Khan

    Citation: Malaria Journal 2018 17:288

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  12. Content type: Correction

    Unfortunately after publication of the original article [1], it came to the author’s attention that there is an error in the caption of Fig. 2.

    Authors: Melchior Kashamuka Mwandagalirwa, Lauren Levitz, Kyaw L. Thwai, Jonathan B. Parr, Varun Goel, Mark Janko, Antoinette Tshefu, Michael Emch, Steven R. Meshnick and Margaret Carrel

    Citation: Malaria Journal 2018 17:287

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    The original article was published in Malaria Journal 2017 16:456

  13. Content type: Research

    The Kingdom of Saudi Arabia is seeking malaria eradication. Malaria transmission has been very low over the last few years. Discovered cases of Plasmodium falciparum infection are assigned a treatment protocol of...

    Authors: Rasha Hassan Soliman, Patricia Garcia-Aranda, Sherine Mohamed Elzagawy, Boshra El-Sayed Hussein, Wael Wahid Mayah, Alexandra Martin Ramirez, Thuy-Huong Ta-Tang and José Miguel Rubio

    Citation: Malaria Journal 2018 17:286

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  14. Content type: Methodology

    Although the use of induced blood stage malaria infection has proven to be a valuable tool for testing the efficacy of vaccines and drugs against Plasmodium falciparum, a limiting factor has been the availability...

    Authors: Rebecca Pawliw, Rebecca Farrow, Silvana Sekuloski, Helen Jennings, Julie Healer, Thuan Phuong, Pri Sathe, Cielo Pasay, Krystal Evans, Alan F. Cowman, Louis Schofield, Nanhua Chen, James McCarthy and Katharine Trenholme

    Citation: Malaria Journal 2018 17:283

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  15. Content type: Research

    Malaria is the leading cause of global paediatric mortality in children below 5 years of age. The number of fatalities has reduced significantly due to an expansion of control interventions but the development...

    Authors: Rachel M. Wiltshire, Christina M. Bergey, Jonathan K. Kayondo, Josephine Birungi, Louis G. Mukwaya, Scott J. Emrich, Nora J. Besansky and Frank H. Collins

    Citation: Malaria Journal 2018 17:285

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  16. Content type: Research

    Since 2006, the artemisinin-based combination therapy (ACT) are recommended to treat uncomplicated malaria including non Plasmodium falciparum malaria in Madagascar. Artesunate–amodiaquine (ASAQ) and artemether–l...

    Authors: Oméga Raobela, Valérie Andriantsoanirina, David Gael Rajaonera, Tovonahary Angelo Rakotomanga, Stéphane Rabearimanana, Fanomezantsoa Ralinoro, Didier Ménard and Arsène Ratsimbasoa

    Citation: Malaria Journal 2018 17:284

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  17. Content type: Methodology

    The study of malaria transmission requires the experimental infection of mosquitoes with Plasmodium gametocytes. In the laboratory, this is achieved using artificial membrane feeding apparatus that simulate body ...

    Authors: Kathrin Witmer, Ellie Sherrard-Smith, Ursula Straschil, Mark Tunnicliff, Jake Baum and Michael Delves

    Citation: Malaria Journal 2018 17:282

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  18. Content type: Research

    Malaria remains endemic in Nigeria despite programmes and policies put in place toward malaria elimination. Long-lasting insecticidal nets have been documented to offer protection from malaria by preventing mo...

    Authors: Stella Babalola, Sulaimon T. Adedokun, Anna McCartney-Melstad, Mathew Okoh, Sola Asa, Ian Tweedie and Andrew Tompsett

    Citation: Malaria Journal 2018 17:280

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  19. Content type: Research

    8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant li...

    Authors: Getasew Shitaye, Endalamaw Gadisa, Lynn Grignard, Girma Shumie, Wakweya Chali, Temesgen Menberu, Mulualem Belachew, Getaneh Tegegn, Sagni Challi, Jonathan Curry, Laleta Mahey, Tsegaye Hailu, Hassen Mamo, Menakath Menon, Taye Balcha, Abraham Aseffa…

    Citation: Malaria Journal 2018 17:281

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  20. Content type: Research

    Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet to be reported in Africa. A population-based mathematical model was use...

    Authors: Nick Scott, Ricardo Ataide, David P. Wilson, Margaret Hellard, Ric N. Price, Julie A. Simpson and Freya J. I. Fowkes

    Citation: Malaria Journal 2018 17:279

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  21. Content type: Research

    Anopheles sacharovi is a dominant malaria vector species in South Europe and the Middle East which has a highly plastic behaviour at both adult and larval stages. Such plasticity has prevented this species from e...

    Authors: Gleb N. Artemov, Alena I. Velichevskaya, Semen M. Bondarenko, Gayane H. Karagyan, Sargis A. Aghayan, Marine S. Arakelyan, Vladimir N. Stegniy, Igor V. Sharakhov and Maria V. Sharakhova

    Citation: Malaria Journal 2018 17:276

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  22. Content type: Correction

    Following publication of the original article [1], one of the authors flagged that unfortunately their last name, Doltario, was incorrectly spelled as ‘Dotrário’.

    Authors: Andréa Beltrami Doltario, Lucas José Bazzo Menon, Valdes Roberto Bollela, Roberto Martinez, Daniel Cardoso de Almeida e Araújo, Benedito Antônio Lopes da Fonseca and Rodrigo de C. Santana

    Citation: Malaria Journal 2018 17:277

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    The original article was published in Malaria Journal 2016 15:294

  23. Content type: Research

    Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a w...

    Authors: Md Atique Ahmed, Yee Ling Lau and Fu-Shi Quan

    Citation: Malaria Journal 2018 17:274

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  24. Content type: Research

    The rapid process of malaria erythrocyte invasion involves ligand–receptor interactions. Inducing antibodies against specific ligands or receptors that abrogate the invasion process is a key challenge for blo...

    Authors: Fauzi Muh, Seong-Kyun Lee, Mohammad Rafiul Hoque, Jin-Hee Han, Ji-Hoon Park, Egy Rahman Firdaus, Robert W. Moon, Yee Ling Lau and Eun-Taek Han

    Citation: Malaria Journal 2018 17:272

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  25. Content type: Research

    Plasmodium 18S rRNA is a biomarker used to monitor blood-stage infections in malaria clinical trials. Plasmodium sporozoites also express this biomarker, and there is conflicting evidence about how long sporozoit...

    Authors: Sean C. Murphy, Andrew S. Ishizuka, Zachary P. Billman, Tayla M. Olsen, Annette M. Seilie, Ming Chang, Nahum Smith, Vorada Chuenchob, Sumana Chakravarty, B. Kim Lee Sim, Stefan H. I. Kappe, Stephen L. Hoffman and Robert A. Seder

    Citation: Malaria Journal 2018 17:275

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  26. Content type: Research

    The development of an effective malarial vaccine is an urgent need. Most glycosylphosphatidylinositol (GPI)-anchored proteins of Plasmodium parasites are exposed to neutralizing antibodies, and several are advanc...

    Authors: Yang Cheng, Bo Wang, Feng Lu, Jin-Hee Han, Md Atique Ahmed and Eun-Taek Han

    Citation: Malaria Journal 2018 17:273

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  27. Content type: Research

    Although Sri Lanka is considered as a malaria-free nation, the threat of re-emergence of outbreaks still remains due to the high prevalence and abundance of malaria vectors. Analysis of population genetic stru...

    Authors: Thilini C. Weeraratne, Sinnathambi N. Surendran, Catherine Walton and S. H. P. Parakrama Karunaratne

    Citation: Malaria Journal 2018 17:271

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  28. Content type: Research

    Plasmodium vivax is the most widespread malarial species, causing significant morbidity worldwide. Knowledge is limited regarding the molecular mechanism of invasion due to the lack of a continuous in vitro cultu...

    Authors: Gabriela Arévalo-Pinzón, María González-González, Carlos Fernando Suárez, Hernando Curtidor, Javier Carabias-Sánchez, Antonio Muro, Joshua LaBaer, Manuel Alfonso Patarroyo and Manuel Fuentes

    Citation: Malaria Journal 2018 17:270

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  29. Content type: Methodology

    Increased engagement of communities has been emphasized in global plans for malaria control and elimination. Three interventions to reinforce and complement national malaria control recommendations were develo...

    Authors: Henk van den Berg, Michèle van Vugt, Alinune N. Kabaghe, Mackenzie Nkalapa, Rowlands Kaotcha, Zinenani Truwah, Tumaini Malenga, Asante Kadama, Saidon Banda, Tinashe Tizifa, Steven Gowelo, Monicah M. Mburu, Kamija S. Phiri, Willem Takken and Robert S. McCann

    Citation: Malaria Journal 2018 17:266

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  30. Content type: Research

    Malaria is an infectious disease that causes many deaths in sub-Saharan Africa. In resource-poor malaria endemic communities, mosquito coils are commonly applied in households to repel the vector mosquito that...

    Authors: Jonathan N. Hogarh, Thomas P. Agyekum, Crentsil Kofi Bempah, Emmanuel D. J. Owusu-Ansah, Silas W. Avicor, Gordon A. Awandare, Julius N. Fobil and Kwasi Obiri-Danso

    Citation: Malaria Journal 2018 17:265

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  31. Content type: Research

    The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in ...

    Authors: Siuhelem Rocha Silva, Anne Cristine Gomes Almeida, George Allan Villarouco da Silva, Rajendranath Ramasawmy, Stefanie Costa Pinto Lopes, André Machado Siqueira, Gabriel Luíz Costa, Taís Nóbrega Sousa, José Luiz Fernandes Vieira, Marcus Vinícius Guimarães Lacerda, Wuelton Marcelo Monteiro and Gisely Cardoso de Melo

    Citation: Malaria Journal 2018 17:267

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  32. Content type: Research

    Plasmodium malariae is characterized by its long asymptomatic persistence in the human host. The epidemiology of P. malariae is incompletely understood and is hampered by the limited knowledge of genetic polymorp...

    Authors: Naowarat Saralamba, Mayfong Mayxay, Paul N. Newton, Frank Smithuis, Francois Nosten, Laypaw Archasuksan, Sasithon Pukrittayakamee, Nicholas J. White, Nicholas P. J. Day, Arjen M. Dondorp and Mallika Imwong

    Citation: Malaria Journal 2018 17:269

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  33. Content type: Research

    A fixed-dose combination of mefloquine with artesunate was evaluated in cases of falciparum malaria in the Brazilian Amazon basin with acceptable efficacy, safety and tolerability. However, there are no data o...

    Authors: Michelle V. D. Ferreira, José L. F. Vieira, Eduardo D. Almeida, Juan G. B. Rivera, Margarete S. M. Gomes and André M. de Siqueira

    Citation: Malaria Journal 2018 17:268

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  34. Content type: Research

    Asymptomatic Plasmodium infections are characterized by the absence of clinical disease and the ability to restrict parasite replication. Increasing levels of regulatory T cells (Tregs) in Plasmodium falciparum i...

    Authors: Augustina Frimpong, Kwadwo Asamoah Kusi, Bernard Tornyigah, Michael Fokuo Ofori and Wilfred Ndifon

    Citation: Malaria Journal 2018 17:263

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  35. Content type: Research

    Pregnant women frequently show low-density Plasmodium infections that require more sensitive methods for accurate diagnosis and early treatment of malaria. This is particularly relevant in low-malaria transmissio...

    Authors: Ana María Vásquez, Lina Zuluaga, Alberto Tobón, Maritza Posada, Gabriel Vélez, Iveth J. González, Ana Campillo and Xavier Ding

    Citation: Malaria Journal 2018 17:262

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  36. Content type: Review

    Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges i...

    Authors: Ngoc Minh Pham, Walter Karlen, Hans-Peter Beck and Emmanuel Delamarche

    Citation: Malaria Journal 2018 17:260

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  37. Content type: Research

    Malaria claims hundreds of thousands of lives each year, most of them children. A “malaria-free world” is the World Health Organization’s vision, but elimination from the southeast Asian Region is hampered by ...

    Authors: Andrés Noé, Sazid Ibna Zaman, Mosiqure Rahman, Anjan Kumar Saha, M. M. Aktaruzzaman and Richard James Maude

    Citation: Malaria Journal 2018 17:259

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  38. Content type: Research

    Artemether–lumefantrine (AL) is the recommended first-line artemisinin-based combination therapy (ACT) for the treatment of uncomplicated falciparum malaria in most of the malaria-endemic countries, including ...

    Authors: Celine I. Mandara, Reginald A. Kavishe, Samuel Gesase, Janneth Mghamba, Esther Ngadaya, Peter Mmbuji, Sigsbert Mkude, Renata Mandike, Ritha Njau, Ally Mohamed, Martha M. Lemnge, Marian Warsame and Deus S. Ishengoma

    Citation: Malaria Journal 2018 17:261

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  39. Content type: Research

    Artemisinin resistance in Plasmodium falciparum has emerged and spread in Southeast Asia. In areas where resistance is established longer courses of artemisinin-based combination therapy have improved cure rates.

    Authors: Kyaw Myo Tun, Atthanee Jeeyapant, Aung Hpone Myint, Zwe Thiha Kyaw, Mehul Dhorda, Mavuto Mukaka, Phaik Yeong Cheah, Mallika Imwong, Thaung Hlaing, Thar Htun Kyaw, Elizabeth A. Ashley, Arjen Dondorp, Nicholas J. White, Nicholas P. J. Day and Frank Smithuis

    Citation: Malaria Journal 2018 17:258

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  40. Content type: Research

    In 2016/2017, Mozambique conducted a countrywide long-lasting insecticidal nets (LLINs) universal coverage campaign (UCC). This paper aims to describe the planning and implementation process of the campaign in...

    Authors: Jorge A. H. Arroz, Baltazar Candrinho, Sílvia Pedro, Guidion Mathe, Mariana da Silva, Sérgio Tsabete, Luis Ismael, Inês Juleca, Marta Chande, Fernando Bambo, Olinda Munguande, Sérgio Julane, Figueiredo Mussambala, Eunice Alfai, Olimpia Muianga, Hermelgildo Matsimbe…

    Citation: Malaria Journal 2018 17:254

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  41. Content type: Research

    Rapid diagnostic tests based on histidine-rich protein 2 (HRP2) detection are the primary tools used to detect Plasmodium falciparum malaria infections. Recent conflicting reports call into question whether α-HRP...

    Authors: Christine F. Markwalter, Lwiindi Mudenda, Mindy Leelawong, Danielle W. Kimmel, Armin Nourani, Saidon Mbambara, Philip E. Thuma and David W. Wright

    Citation: Malaria Journal 2018 17:256

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  42. Content type: Research

    Insecticide-treated bed nets (ITNs) have played a large role in reducing the burden of malaria. There is concern however regarding the potential of the mass distributions and use of ITNs to select for insectic...

    Authors: Chris Stone and Kevin Gross

    Citation: Malaria Journal 2018 17:257

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  43. Content type: Research

    As malaria transmission decreases, the proportion of infections that are asymptomatic at any given time increases. This poses a challenge for diagnosis as routinely used rapid diagnostic tests (RDTs) miss asym...

    Authors: Munyaradzi Tambo, Joyce R. Auala, Hugh J. Sturrock, Immo Kleinschmidt, Ronnie Bock, Jennifer L. Smith, Roland Gosling and Davis R. Mumbengegwi

    Citation: Malaria Journal 2018 17:255

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  44. Content type: Research

    Although the recent decline of malaria burden in some African countries has been attributed to a scale-up of interventions, such as bed nets (insecticide-treated bed nets, ITNs/long-lasting insecticidal nets, ...

    Authors: Deus S. Ishengoma, Bruno P. Mmbando, Celine I. Mandara, Mercy G. Chiduo, Filbert Francis, Wilbert Timiza, Hellen Msemo, Agnes Kijazi, Martha M. Lemnge, Mwelecele N. Malecela, Robert W. Snow, Michael Alifrangis and Ib C. Bygbjerg

    Citation: Malaria Journal 2018 17:252

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  45. Content type: Research

    The haemolysis associated with clinical episodes of malaria results in the liberation of haem, which activates the enzyme haem oxygenase-1 (HO-1). HO-1 has been shown to reduce neutrophil function and increase...

    Authors: Jason P. Mooney, Aissata Barry, Bronner P. Gonçalves, Alfred B. Tiono, Shehu S. Awandu, Lynn Grignard, Chris J. Drakeley, Christian Bottomley, Teun Bousema and Eleanor M. Riley

    Citation: Malaria Journal 2018 17:253

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  46. Content type: Research

    The spread of SP resistance may compromise the effectiveness of intermittent preventive treatment of malaria in pregnancy (MiP) with sulfadoxine–pyrimethamine (IPTp-SP) across Africa. However, there is no reco...

    Authors: Ekpereonne Esu, Nicole Berens-Riha, Michael Pritsch, Nuria Nwachuku, Thomas Loescher and Martin Meremikwu

    Citation: Malaria Journal 2018 17:251

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  47. Content type: Research

    Mutations in the Plasmodium falciparum k13 gene are associated with artemisinin (ART) resistance. However, it is unclear whether the F446I mutation, the most prevalent allele at the China–Myanmar border and north...

    Authors: Jing Wang, Yufu Huang, Yuemeng Zhao, Run Ye, Dongmei Zhang and Weiqing Pan

    Citation: Malaria Journal 2018 17:248

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