Skip to main content

Table 1 IC50 values for oxidative stress inducers and an aminotransferase inhibitor for D10 and D10Δgdhaclones

From: Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development

  

IC50values (μM)

 

Parasite line

N-methylphenazonium methosulfate

Tert -butylhydroperoxide

L-cycloserine

D10

0.8 ± 0.2

76.7 ± 20.0

145.8 ± 56.6

D10Δgdha-1

0.7 ± 0.2

81.8 ± 17.2

113.5 ± 37.5

D10Δgdha-2

0.7 ± 0.1

81.3 ± 15.5

111.9 ± 37.4

  1. The effect on parasite viability by the endogenous stressor N-methylphenazonium methosulfate, the exogenous stressor tert-butylhydroperoxide and the aminotransferase inhibitor L-cycloserine were determined by the incorporation of [3H]-hypoxanthine in the presence of increasing drug concentrations. The IC50 values were calculated by non linear regressing of the sigmoidal dose-response equation and shown are the mean ± S.D. of two (N-methylphenazonium methosulfate) or three (tert-butylhydroperoxide) independent experiments. For L-cycloserine the mean ± S.E.M of six independent experiments is shown.
Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us