Laboratory prediction of the requirement for renal replacement in acute falciparum malaria

Malaria Journal

Table 7 Sensitivity, specificity, and the positive and negative predictive values of various selected laboratory tests performed on admission to predict the later requirement for dialysis^: optimal cut-offs in this series

Index	Optimal cut off**	Sensitivity	Specificity	PPV	NPV
Plasma creatinine μmol/L	202	77	78	75	80
RFI	1.4	71	72	69	74
FeNa	1.88	50	91	83	67
Urine Osmolality mosm/L	419	63	56	56	63
UPCR	43	84	44	57	76
Urinary Sodium mmol/L	34	90	44	59	83
Bicarbonate	15	82	56	62	78
NGAL	510	65	70	65	70

AUC: Area under receiver operating characteristic curve, RFI: Renal failure index, FeNa: Fractional excretion of sodium, UPCR: Urine: plasma creatinine ratio, FUN: Fractional excretion urea. NGAL: neutrophil gelatinase-associated lipocalcin.
** Determined using the ROC curve
^ Patients who should have had dialysis.

ISSN: 1475-2875