In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Table 1 In vitro activity of dehydrobrachylaenolide against P. falciparum.

Compound	D10 IC₅₀ (μM) n = 8	K1 IC₅₀ (μM) n = 4	CHO IC₅₀ (μM) n = 2	D10 TI	K1 TI
Dehydrobrachylaenolide	1.865 ± 0.254	4.095 ± 0.579	17.199	9.2	4.2
Chloroquine	0.038	0.200	35.800	942	179

D10 = P. falciparum - chloroquine-sensitive strain
K1 = P. falciparum - chloroquine-resistant strain
CHO = Chinese hamster ovary cells
n = number of technical replicates averaged - each independent experiment performed in duplicate
TI = Therapeutic index i.e. CHO IC₅₀/anti-plasmodial IC₅₀

ISSN: 1475-2875