| Pregnant cases |  | P-value | |||
---|---|---|---|---|---|---|
Parameters | Ante-partum | Post-partum (3 months) | Non-pregnant controls | Ante vs. Post* | Ante vs. Non-pregnant controls†| Post vs. Non-pregnant controls†|
Cmax (ng/mL) | 904.6 [363.9 - 2541.9] | 979.5 [414.5 - 2246.3] | 1284.7 [539.8 - 3259.4] | 0.89 | 0.24 | 0.090 |
Tmax (h) | 1.50 [0.25 - 6.00] | 1.50 [0.50 - 4.00] | 1.52 [0.50 - 4.03] | 0.95 | 0.57 | 0.34 |
AUCall (ng*h/mL) | 1730.5 [1034.7 - 4085.5] | 2122.2 [1308.9 - 4054.9] | 2787.0 [1244.8 - 6363.5] | 0.0080 | 0.0018 | 0.021 |
AUCfree (ng*h/mL) | 398.5 [138.7 - 663.9] | 373.0 [186.5 - 708.3] | 504.6 [197.9 - 1301.3] | 0.80 | 0.057 | 0.043 |
CL/F (L/h) | 85.5 [36.2 - 142.9] | 69.7 [36.5 - 113.0] | 53.1 [23.2 - 118.8] | 0.0035 | 0.0018 | 0.021 |
CL/F (L/kg/h) | 1.39 [0.75 - 2.46] | 1.26 [0.63 - 2.32] | 1.07 [0.53 - 1.89] | 0.033 | 0.0025 | 0.011 |
T½ (h) | 1.28 [0.83 - 2.71] | 1.63 [0.92 - 2.18] | 1.41 [0.86 - 6.55] | 0.021 | 0.28 | 0.27 |
Vd/F (L) | 157.4 [59.9 - 335.9] | 158.3 [66.0 - 332.7] | 128.2 [38.5 - 400.1] | 0.82 | 0.098 | 0.071 |
Vd/F (L/kg) | 2.84 [1.25 - 5.33] | 3.00 [1.55 - 5.37] | 2.45 [0.78 - 6.56] | 0.54 | 0.17 | 0.083 |
FF | 0.21 [0.13 - 0.31] | 0.19 [0.11 - 0.27] | 0.18 [0.09 - 0.39] | 0.014 | 0.031 | 0.82 |