Figure 1

Plasmodium knowlesi static binding assay. On admission to the study this patient had predominantly ring (immature trophozoite) stage parasites (a). Following a period of in vitro culture the parasites matured, in this case to late trophozoite stages, as required for the static binding assay (b). Infected erythrocytes bound to an ICAM-1 coated area of the assay dish are marked with arrows (c).