Figure 3
From: The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
Dissemination of malaria parasites by IVIS imaging of C57BL /6 Wild-type (WT), CYP 2D knockout, and humanized CYP 2D knockout /CYP 2D6 knock-in mice at 24 - hr and 72 - hr post-inoculation with luciferase expressing Plasmodium berghei . WT animals treated with 20 mg/kg x 3 days of oral PQ exhibited no parasitaemia at 24 or 72 hr. All five CYP 2D knockout mice exhibited liver stage parasitaemia at 24 hr which progressed to systemic infection by 72 hr. PQ efficacy was largely restored in mice in which the deleted CYP 2D cluster was replaced with human CYP 2D6.