Drug | Metabolism | Concomitant medications taken by study patients | Effect†| %* |
---|---|---|---|---|
Artemether | Â | Â | 0% | |
 | Ibuprofen, pyrimethamine and quinine | Strong to moderate inhibitor | 22% | |
 | CYP2C19‡ [34] |  |  | 0% |
 | Caffeine, doxycycline, erythromycine and metronidazole | Moderate inhibitors | 10% | |
 |  |  | 0% | |
Dihydroartemisinin | Glucuronidation [36] | -- | Â | Â |
Lumefantrine | Caffeine, doxycycline, erythromycine and metronidazole | Moderate inhibitors | 10% | |
Mefloquine | Clarithromycine, caffeine, metronidazole and tetracycline | Strong to moderate inhibitor | 8% | |
 | CYP3A5[37] |  |  | 0% |
Piperaquine | Unknown [31] | Chloroquine, ibuprofen and quinine | Strong to moderate inhibitor of CYP2C8, CYP2C9 and / or CYP2D6 | 45% |