Population analysis | Bootstrap evaluation | ||||||
---|---|---|---|---|---|---|---|
Parameter | Estimate | S.E.a | IIVb | S.E.c | Mean of 200 | S.E. | 95% C.I.d |
Artemether | Â | Â | Â | Â | Â | Â | Â |
CL [L/h/kg] | 24.7 × BW0.75 | 10% | 44% | 17% | 24.4 × BW0.75 | 10% | 19–29 |
θ INH | −0.3 | 45% |  |  | −0.27 | 60% | 0.5–1.1 |
V C [L/kg] | 129 | 20% |  |  | 133 | 26% | 88–232 |
V M [L] | Fixed to V C | Â | Â | Â | Â | Â | Â |
ka [h-1] | 0.27 | 11% | 119% | 11% | 0.27 | 14% | 0.21–0.35 |
k23 [h-1] | 5.86 | 21% | 68% | 9% | 5.83 | 25% | 3.6–9.7 |
CL met [L/h] | 419 | 30% |  |  | 440 | 42% | 213–927 |
σ C (CV%) | 74% | 9% c |  |  | 73% | 11% c | 59%–86% |
σ M (CV%) | 119% | 11% c |  |  | 116% | 9% c | 88%–149% |
Lumefantrine | Â | Â | Â | Â | Â | Â | Â |
CL [L/h/kg] |
| 28% | 38% | 14% |
| 24% | 0.51-1.37 |
θ BWCL | 0.52 | 19% |  |  | 0.51 | 14% | 0.36-0.65 |
V C [L/kg] |
| 28% | 33% | 11% |
| 24% | 35.1–91.9 |
θ BWVC | 0.35 | 28% |  |  | 0.34 | 19% | 0.19-0.45 |
V M [L] | Fixed to V C | Â | Â | Â | Â | Â | Â |
k a [h-1] | 0.54 | 31% |  |  | 0.48 | 43% | 0.11–0.88 |
F0 [mg] | 2.53 | 14% | 103% | 14% | 2.45 | 15% | 1.58–3.28 |
k23 [h-1] | 3.7 × 10-4 | 12% | 38% | 15% | 3.7 × 10-4 | 9% | (3.0–4.4) × 10-4 |
CL met [L/h] | 4.8 | 10% |  |  | 4.6 | 13% | 3.4–5.7 |
σ C (CV%) | 60% | 9% c |  |  | 61% | 31% | 55%–77% |
σ M [μmolL-1] | 0.013 | 4% c |  |  | 0.013 | 45% | 0.010–0.016 |
Mefloquine | Â | Â | Â | Â | Â | Â | Â |
CL [L/h/kg] | 0.10 × BW0.75 | 5% | 12% | 88% | 0.10 × BW0.75 | 5% | (0.09–0.11) |
V C [L/kg] | 8.93 × BW | 6% | 19% | 96% | 9.01 × BW | 6% | (8.04–10.20) |
ka [h-1] | 0.15 | 14% |  |  | 0.15 | 14% | 0.12–0.19 |
F0 [mg] | 33.1 | 56% | 175% | 48% | 31.0 | 43% | 11.8–48.1 |
σ C [μmolL-1] | 43% | 6% c |  |  | 43% | 6% c | 0.14–0.22 |
Piperaquine | Â | Â | Â | Â | Â | Â | Â |
CL [L/h/kg] | 4.50 × BW0.75 | 13% | 45% | 61% | 4.26 × BW0.75 | 22% | (3.24–5.76) |
V C [L/kg] | 346 × BW | 12% | 65% | 48% | 347 × BW | 13% | (260–432) |
Q [L/h] | 122 | 13% |  |  | 126 | 13% | 86–158 |
V P [L] | 18,600 | 22% | 50% | 77% | 20,053 | 37% | 8,778–28,422 |
ka [h-1] | 0.93 | 28% |  |  | 1.00 | 34% | 0.35–1.52 |
F0 [mg] | 123 | 18% |  |  | 125 | 18% | 75–171 |
σ C [μmolL-1] | 41% | 10% c |  |  | 41% | 6% c | 0.14–0.21 |