Figure 3

Activity of CSP antibodies in the ILSDA. A: CSP antibodies demonstrate concentration-dependent inhibition of liver stage development in CPHH. 25 k P. falciparum (Pf) sporozoites were mixed with NFS-1 at six different concentrations (0.0003, 0.0016, 0.008, 0.04, 0.2, or 1.0 μg/mL) and inoculated into CPHH. Hepatocytes were analysed after 96 hours of sporozoite inoculation. Pf 18s rRNA copy numbers were measured by qRT-PCR. Each data point shows the mean of a duplicate sample. B: Effects of NFS-1 (10 μg/mL) on the sporozoites ability to invade (1D = 1 day) and develop (4D = 4 days) in CPHH. Error bars represent the standard deviation of the mean.