Compound | Assay 1 (A1): | Conclusion A1 | Assay 2 (A2): | Conclusion A2 | Concluded speed of action |
---|---|---|---|---|---|
IC50 speed assay | Stage specificity analysis | ||||
(ratio of IC50 24 h/IC50 72 h)a | (at 6-100x IC50) | ||||
Chloroquine | 1.1 | Fast | >95% action on Rb | Fast (cidal) | Fast (cidal) |
>95% action on Sb | |||||
Artesunate | 1.1 | Fast | >95% action on R | Fast (cidal) | Fast (cidal) |
>95% action on S | |||||
Atovaquone | 3.6 | Not fast | ~50-70% action on R | Not fast (cidal) | Not fast (cidal) |
~75-90% action on S | |||||
Pyrimethamine | 8.3 | Not fast | ~5% action on R | Not fast (cidal) | Not fast (cidal) |
~90% action on S | |||||
1 | 4.3 | Not fast | ~0-75% action on R | Not fast (cidal) | Not fast (cidal) |
>95% action on S | |||||
2 | 1.6 | Fast/Not fast | ~40- >95% action on R | Not fast (cidal) | Not fast |
>95% action on S | |||||
3 | 1.2 | Fast | >95% action on R | Fast (cidal) | Fast (cidal) |
>95% action on S |