Susceptibility of human Plasmodium knowlesi infections to anti-malarials

Malaria Journal

Table 2 P. knowlesi drug sensitivity data

Drug	IC₅₀values (nM) for *P. knowlesi* isolates (maturation assay)^a	IC₅₀values (nM) for *P. knowlesi* H strain ( p LDH assay)^b
Mefloquine	26 (± 3.1)	25 (7.4 to 81)^c
Chloroquine	23 (± 4.8)	3.2 (2.2 to 4.7)
Artemisinin	2.1 (± 0.99)	0.80 (0.35 to 1.9)^c
Artemether	0.90 (± 0.19)	0.84 (0.34 to 2.1)^c
Artesunate	0.90 (± 0.12)	2.0 (0.93 to 4.2)^c
DHA	1.6 (± 0.92)	0.79 (0.62 to 1.0)

^aMean (± SEM), from 6 independent experiments (each of which was performed in triplicate).
^bMean (95% CIs), from a single experiment repeated in quintuplicate.
^cR² < 0.8.
IC₅₀ values are presented for six anti-malarials on P. knowlesi field isolates and laboratory H strain.

ISSN: 1475-2875