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Table 2 Comparison of IC 50 derived from bioluminescence and fluorescence-based assays

From: Evaluation of bioluminescence-based assays of anti-malarial drug activity

Drug1 MSF Luc MSF Luc
  Dd2attB Dd2luc Dd2attB NF54attB NF54luc NF54luc
Artemether 12.0 ± 0.5 11.3 ± 0.3 8.4 ± 0.8 12.1 ± 1.3 13.1 ± 0.9 12.2 ± 0.9
Atovaquone 1.9 ± 0.4 1.3 ± 0.6 1.7 ± 0.1 0.7 ± 0.6 0.9 ± 0.2 2.9 ± 0.3
Azithromycin >1580 >1580 >1580 >1580 >1580 >1580
Cloroquine 22.6 ± 2.5 26.4 ± 1.0 18.6 ± 2.5 26.7 ± 1.0 13.2 ± 2.1 21.0 ± 1.3
Dihydroartemisinin 133.0 ± 7.8 125.6 ± 2.4 166.3 ± 7.4 7.9 ± 0.7 14.1 ± 2.2 19.4 ± 1.8
Mefloquine 4.4 ± 0.5 7.8 ± 1.2 6.0 ± 0.4 9.7 ± 1.4 7.1 ± 1.2 5.6 ± 0.3
Quinine 173.5 ± 13.0 157.3 ± 20.0 115.4 ± 9.1 62.6 ± 5.7 69.0 ± 3.2 48.5 ± 4.0
WR99210 nd2 nd nd nd 0.55 ± 0.13 0.48 ± 0.21
  1. 1IC50 values (n.3 independent measurements in the triplicate) reported as mean ± standard deviation in nM, 2not done.