Table 2 Comparison of IC 50 derived from bioluminescence and fluorescence-based assays
From: Evaluation of bioluminescence-based assays of anti-malarial drug activity
Drug1 | MSF | Luc | MSF | Luc | ||
|---|---|---|---|---|---|---|
Dd2attB | Dd2luc | Dd2attB | NF54attB | NF54luc | NF54luc | |
Artemether | 12.0 ± 0.5 | 11.3 ± 0.3 | 8.4 ± 0.8 | 12.1 ± 1.3 | 13.1 ± 0.9 | 12.2 ± 0.9 |
Atovaquone | 1.9 ± 0.4 | 1.3 ± 0.6 | 1.7 ± 0.1 | 0.7 ± 0.6 | 0.9 ± 0.2 | 2.9 ± 0.3 |
Azithromycin | >1580 | >1580 | >1580 | >1580 | >1580 | >1580 |
Cloroquine | 22.6 ± 2.5 | 26.4 ± 1.0 | 18.6 ± 2.5 | 26.7 ± 1.0 | 13.2 ± 2.1 | 21.0 ± 1.3 |
Dihydroartemisinin | 133.0 ± 7.8 | 125.6 ± 2.4 | 166.3 ± 7.4 | 7.9 ± 0.7 | 14.1 ± 2.2 | 19.4 ± 1.8 |
Mefloquine | 4.4 ± 0.5 | 7.8 ± 1.2 | 6.0 ± 0.4 | 9.7 ± 1.4 | 7.1 ± 1.2 | 5.6 ± 0.3 |
Quinine | 173.5 ± 13.0 | 157.3 ± 20.0 | 115.4 ± 9.1 | 62.6 ± 5.7 | 69.0 ± 3.2 | 48.5 ± 4.0 |
WR99210 | nd2 | nd | nd | nd | 0.55 ± 0.13 | 0.48 ± 0.21 |