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Table 3 Association between levels of antibodies (two-fold increment) at 5.5 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

  

5.5-24 months

Antigens

Antibodies

Crude

Adjusted

  

IRR1

95% CI

P value2

IRR

95% CI

P value

MSP-119

IgG

1.09

0.90; 1.33

0.3783

0.96

0.78; 1.17

0.6853

IgG1

1.10

0.90; 1.33

0.3525

0.96

0.79; 1.17

0.6872

IgG2

1.33

0.72; 2.45

0.3594

1.05

0.61; 1.83

0.8519

IgG3

1.20

0.87; 1.65

0.2508

0.93

0.67; 1.29

0.6599

IgG4

0.66

0.27; 1.60

0.3526

0.48

0.21; 1.14

0.0970

IgM

1.35

0.96; 1.89

0.0768

1.27

0.88; 1.85

0.2013

AMA-1

IgG

2.01

1.58; 2.56

< 0.0001

1.64

1.29; 2.09

< 0.0001

IgG1

1.81

1.48; 2.22

< 0.0001

1.54

1.25; 1.89

< 0.0001

IgG2

1.12

0.75; 1.66

0.5840

0.91

0.61; 1.36

0.6415

IgG3

1.38

1.05; 1.82

0.0169

1.15

0.89; 1.47

0.2803

IgG4

1.27

0.69; 2.33

0.4396

0.94

0.50; 1.78

0.8496

IgM

1.33

0.89; 2.00

0.1590

1.16

0.79; 1.70

0.4468

EBA-175

IgG

1.29

1.04; 1.60

0.0177

1.11

0.90; 1.37

0.3323

IgG1

1.36

1.08; 1.72

0.0077

1.21

0.97; 1.50

0.0916

IgG2

1.21

0.69; 2.12

0.4981

1.21

0.72; 2.04

0.4614

IgG3

1.34

0.97; 1.83

0.0701

1.20

0.89; 1.63

0.2324

IgG4

0.91

0.45; 1.82

0.7837

1.09

0.57; 2.07

0.7936

IgM

1.57

1.04; 2.38

0.0338

1.41

0.94; 2.12

0.0996

VSA

IgG

1.42

1.10; 1.84

0.0069

1.55

1.19; 2.01

0.0008

  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.