Drug parameter | Artemether + lumefantrine | Dihydroartemisinin + piperaquine | |||
---|---|---|---|---|---|
 | AM | DHA | LF | DHA | PPQ |
Vd (L/kg) | 46.6 (82) | 15 (48) | 21 (263) | 1.49 (48) | 150 (42) |
x (/day) | 23.98 (68) | – | – | – | – |
z (/day) | 11.97 (65) | – | – | – | – |
k (/day) | – | 44.15 (23) | 0.16 (5) | 19.8 (23) | 0.03 (54) |
IC50 (mg/L) | 0.0023 (79) | 0.009 (117) | 0.032 (102) | 0.009 (117) | 0.088 (30) |
Vmax | 27.6 | 27.6 | 3.45 | 27.6 | 3.45 |
n | 4 | 4 | 4 | 4 | 6 |