Treatment scenario | Treatment outcome | Age-based dosing regimen | Weight-based dosing regimen | ||||||
---|---|---|---|---|---|---|---|---|---|
 |  | Global | Africa | Asia | Latin America | Global | Africa | Asia | Latin America |
Full course, i e, once daily over three days at 0, 24 and 48Â hours | All parasites cleared | 90.53 | 91.03 | 90.33 | 92.21 | 97.73 | 97.49 | 97.78 | 97.36 |
Parasites below LoD | 0.40 | 0.47 | 0.36 | 0.40 | 0.41 | 0.38 | 0.40 | 0.46 | |
Recrudescence | 8.50 | 7.93 | 8.67 | 6.98 | 1.82 | 2.10 | 1.80 | 2.11 | |
Parasites always above LoD | 0.57 | 0.57 | 0.64 | 0.41 | 0.04 | 0.03 | 0.02 | 0.07 | |
Second dose missed | All parasites cleared | 69.24 | 69.75 | 68.32 | 72.70 | 90.68 | 89.7 | 91.06 | 88.8 |
Parasites below LoD | 0.50 | 0.55 | 0.54 | 0.45 | 0.52 | 0.60 | 0.49 | 0.65 | |
Recrudescence | 24.01 | 23.73 | 24.68 | 21.92 | 8.13 | 8.91 | 7.76 | 9.59 | |
Parasites always above LoD | 6.25 | 5.97 | 6.46 | 4.93 | 0.67 | 0.79 | 0.69 | 0.96 | |
Third dose missed | All parasites cleared | 70.46 | 71.16 | 69.83 | 74.02 | 91.2 | 90.34 | 91.61 | 89.48 |
Parasites below LoD | 0.50 | 0.50 | 0.48 | 0.44 | 0.48 | 0.58 | 0.45 | 0.62 | |
Recrudescence | 24.28 | 23.76 | 24.75 | 22.01 | 7.77 | 8.45 | 7.45 | 9.16 | |
Parasites always above LoD | 4.76 | 4.58 | 4.94 | 3.53 | 0.55 | 0.63 | 0.49 | 0.74 | |
Second and third dose missed | All parasites cleared | 27.06 | 27.64 | 26.04 | 30.01 | 51.90 | 49.55 | 52.23 | 48.77 |
Parasites below LoD | 0.32 | 0.31 | 0.32 | 0.34 | 0.61 | 0.47 | 0.59 | 0.44 | |
Recrudescence | 31.06 | 31.02 | 31.37 | 31.53 | 31.25 | 31.91 | 31.42 | 31.63 | |
Parasites always above LoD | 41.56 | 41.03 | 42.27 | 38.12 | 16.24 | 18.07 | 15.76 | 19.16 | |
Second and third dose delayed by 24Â hours | All parasites cleared | 89.80 | 90.18 | 89.48 | 91.55 | 97.62 | 97.36 | 97.65 | 97.19 |
Parasites below LoD | 0.44 | 0.47 | 0.41 | 0.40 | 0.41 | 0.40 | 0.44 | 0.47 | |
Recrudescence | 8.96 | 8.54 | 9.29 | 7.42 | 1.93 | 2.20 | 1.88 | 2.24 | |
 | Parasites always above LoD | 0.80 | 0.81 | 0.82 | 0.63 | 0.04 | 0.04 | 0.03 | 0.10 |