Figure 7
From: Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum
Two-dimensional Principal Component Analysis similarity scatterplot defining the chemical space of the 178 initial hits. Details as per 61 remaining compounds by cluster number. Each point is a compound encoded as 1024-bit Dotmatics FPCA fingerprint. Yellow triangles denote commercial anti-malarial drugs along with their abbreviation. Green circles denote hits that passed all the physicochemical, novelty and substructural filters, while the orange rhombi denote compounds that belong to the final validated hit set. The subset of the initial 178 remaining compounds that did not advance through the cascade is highlighted in light grey.