Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study

Table 1 Minor allele frequencies and test of Hardy-Weinberg equilibrium in selected candidate SNPs

Gene	Alternate SNP name	SNP	Location	Minor allele frequency			HWE^†
Gene	Alternate SNP name	SNP	Location	Maj/Min	Cases (n = 971)	Controls (n = 891)	(P value)
HBB	HbS	rs334	Genic	A/T	0.054	0.088	0.189
GBP7		rs1803632	P	C/G	0.474	0.497	0.074
DARC		rs2814778	UTR	A/G	0.006	0.003	1.000
CR1		rs17047660	UTR	A/G	0.283	0.301	0.409
CR1		rs17047661	Genic	G/A	0.277	0.272	0.379
C6		rs1801033	Genic	A/C	0.415	0.417	0.515
CTL4		rs2242665	Genic	A/G	0.319	0.324	0.642
NOD1		rs2075820	P	G/A	0.401	0.397	0.170
CD36		rs3211938	Genic	T/G	0.144	0.148	0.409
CFTR		rs17140229	Genic	C/T	0.401	0.408	0.129
ABO		rs8176746	Genic	C/A	0.166	0.170	0.173
TRIM5		rs7935564	Genic	G/A	0.486	0.486	0.273
RTN3		rs542998	Genic	C/T	0.379	0.384	0.375
SPTB		rs229587	Genic	T/C	0.290	0.291	0.669
ADCY9		rs2230739	Genic	A/G	0.092	0.104	0.434
ADCY9		rs10775349	Genic	C/G	0.151	0.169	0.462
ADORA2B		rs2535611	Genic	T/C	0.099	0.110	0.715
NOS2		rs2297518	Genic	G/A	0.105	0.139	0.552
NOS2	NOS2-954	rs1800482	UTR	G/C	0.082	0.080	0.812
NOS2		rs9282799	UTR	C/T	0.040	0.036	0.076
NOS2	NOS2-1659	rs8078340	UTR	C/T	0.270	0.280	0.200
EMR1		rs373533	Genic	G/T	0.444	0.463	0.942
EMR1		rs461645	Genic	C/T	0.446	0.468	1.000
ICAM1	ICAM-1codon469	rs5498	Genic	A/G	0.119	0.141	0.238
GNAS	GNAS_8386	rs8386	Genic	C/T	0.159	0.154	0.224
DERL3		rs1128127	Genic	A/G	0.464	0.457	0.481
CD40LG_(F)		rs3092945	P	T/C	0.295	0.269	0.359
CD40LG_(M)		rs3092945	P	T/C	0.295	0.257	< 0.001
CD40LG_(F)		rs1126535	Genic	T/C	0.188	0.161	0.190
CD40LG_(M)		rs1126535	Genic	T/C	0.159	0.216	< 0.001
G6PD_(F)		rs1050829	P	T/C	0.360	0.333	0.342
G6PD_(M)		rs1050829	P	T/C	0.360	0.341	< 0.001
G6PD_(F)		rs1050828	P	C/T	0.031	0.089	0.711
G6PD_(M)		rs1050828	P	C/T	0.120	0.106	< 0.001

UTR 3’untranslated region, P promoter, Maj/Min = Major/Minor allele, M = male, F = Female ^†One degree of freedom χ 2 test of HWE applied to the 891 controls.

ISSN: 1475-2875