High plasma levels of HLA-G are associated with low birth weight and with an increased risk of malaria in infancy

Malaria Journal

Table 4 Factors associated to the level of sHLA - G in peripheral blood in the first year of life using linear multivariate mixed regression

Covariates		Estimation	95% CI	p-value
Environmental risk	Very low ≤0.66 (n = 93)
	Low]0.66-1.85] (n = 109)	0.41	0.13; 0.70	0.005
	Median]1.85-4.81] (n = 95)	0.32	0.03; 0.61	0.032	0.032
	High >4.81 (n = 100)	0.36	0.04; 0.67	0.026
sHLA- G in cord blood	Continuous (n = 397)	1.13	0.73; 1.53	<10^-3
Low birth weight	No (n = 369)
Low birth weight	Yes (n = 28)	1.03	0.31; 1.75	0.005
Age of infant (months)	3 (n = 100)
	6 (n = 103)	0.30	0.04; 0.56	0.023
	9 (n = 100)	0.76	0.49; 1.03	<10^-3	<10^-3
	12 (n = 94)	0.79	0.52; 1.07	<10^-3

Estimation represents regression coefficients which can be positive or negative. Regression coefficients measure the increase (positive value) or decrease (negative value) of the dependent variable (level of sHLA-G in peripheral blood in the first year of life) due to the presence of independent ones. Covariates included in linear multivariate mixed regression were environmental risk, sHLA-G quantification in cord blood, Low birth weight, age, malaria infection occurring during the trimester preceding blood draws and placental infection. Covariates with significant p values were presented in the Table 4.

ISSN: 1475-2875