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Table 6 Logistic regression analysis of TNF −863 C/A and IFN-γ -1616 T/C genotypes in association to TNF and IFN-γ concentration (pg/mL) respectively in the combined study groups

From: IFN-gamma and TNF associated with severe falciparum malaria infection in Saudi pregnant women

Genotypes

OR‡ (95% CI)

P value

TNF −863

  

CC

4.04 (2.01- 8.13)

<0.001

CA

1.00

 

AA

0.31 (0.11- 0.86)

0.024

IFN-γ -1616

  

TT

8.49 (4.03- 17.91)

<0.001

TC

1.00

 

CC

0.81 (0.33- 1.92)

0.002

  1. ‡OR represent odds ratios while CI represents confidence intervals. Lower levels of TNF (mean ± SD; 2.99 ± 1.24) and IFN-γ (4.01 ± 1.94) concentration were assigned 0 while severe malaria (SM) patients were assigned 1 in the logistic regression analysis. OR above 1 represented value associated to SM patients while less than 1 value represented to UM patients.
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Malaria Journal

ISSN: 1475-2875

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