| Base model | Final model |
---|
Parameter | Mean | Standard error | Mean | Standard error |
---|
KaAS(h−1) | 2.45 | 0.34 | 2.41 | 0.34 |
CL/FAS (L/h) | 797 | 102 | 616 | 98.4 |
V/FAS(L) | 119 | 51.8 | 85.2 | 36.0 |
FM(%) | 0.81 | 0.16 | 0.00781 | 0.00108 |
Kem (h−1) | 0.819 | 0.266 | 0.742 | 0.166 |
ѲBWkem | NA | NA | 1.65 | 0.46 |
ѲFORM | NA | NA | 1.79 | 0.36 |
ω2CL/FAS | 0.101 | 0.089 | NE | NE |
ω2V/FAS | 1.94 | 2.23 | 2.21 | 2.27 |
ω2kemDHA | 0.000352 | 0.0666 | NE | NE |
σ2adAS | 0.000218 | 0.000122 | 0.000277 | 0.00015 |
σ2multAS | 0.665 | 0.154 | 0.674 | 0.116 |
σ2adDHA | 0.0438 | 0.0299 | 0.0324 | 0.0223 |
σ2multDHA | 0.391 | 0.093 | 0.374 | 0.0726 |
- KaAS: absorption rate constant of AS, CL/FAS: apparent clearance of AS, V/FAS: apparent distribution volume of AS, FM: fraction of AS metabolized into DHA, K34 and K43: distribution rate constants of DAQ, Kem: elimination rate constant of DHA, ѲBWkm: influential factor of BW on DHA kem, ѲFORM : influence of dosage form on AS bioavailability, ω2CL/FAS: interindividual variability of CL/FAS, ω2V/FAS: interindividual variability of V/FAS, σ2multAS: proportional residual error for AS, σ2adAS: additive residual error for AS , σ2multDHA: proportional residual error for DHA, σ2adDHA: additive residual error for DHA, NA: Not Available, NE: Not Estimated.