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Table 1 Description of the studies included in the review on the use of artemisinin in pregnancy.

From: The safety of artemisinins during pregnancy: a pressing question

Study site, year Reference Study Population Antimalarial treatment Primary Outcomes
Randomized trials*
Nigeria, 1994–1997 [14] Pregnant women infected with P. falciparum malaria after treatment failure§ 1) Artemether IM + mefloquine n = 22
2) Artemether IM n = 23
Artemether overall dosage: 3.2–9.6 mg/kg
Parasitaemia at day 28; AEs
Foetal outcomes; infant neurodevelopment
Thailand, 1995–1998 [10] Pregnant women infected with P. falciparum malaria§ 1)Quinine n = 29
2)Artesunate+ mefloquine n = 28
Artesunate overall dose: 12 mg/kg
Time to parasite & fever clearance; anaemia; AEs; neurological examination
Perinatal assessment; birth outcomes; infant physical and neurological assessment
TBB, 1995–1997 [12] Pregnant women with uncomplicated P. falciparum malaria 1)Quinine n = 42
2)Artesunate+mefloquine n = 66
Artesunate overall dose: 12 mg/kg
Parasite clearance; anaemia; AEs; neurological deficit
Birth outcomes; infant developmental milestones
TBB, 1997–2000 [13] Pregnant women with uncomplicated P. falciparum malaria 1)Quinine+clindamycin n = 65
2) Artesunate n = 64
Artesunate overall dose: 12 mg/kg
Treatment failure at day 42 or before delivery; anaemia; AEs
Birth outcomes; infant developmental milestones
TBB, 2001–2003 [11] Pregnant women with uncomplicated P. falciparum or mixed malaria 1)Quinine n = 42
2) Artesunate atovaquone-proguanil n = 39
Artesunate overall dose: 12 mg/kg
Fever, parasite clearance; treatment failure at day 63; anaemia; AEs
Birth outcomes; infant developmental milestones
Case series
China, 1976–1980 [15] Pregnant women infected with P. falciparum or P vivax malaria§
Trimesters (n): 3rd (1), 2nd (5)
Artemisinin IM or Artemether
Overall artemisinins dose: 500–900 mg
Therapeutic effects and adverse reactions for mother and child
TBB, 1992–1996 [17] Pregnant women with uncomplicated multi-drug resistant P. falciparum or mixed malarial infection
Trimesters (n): 3rd & 2nd (74), 1st (16)
Artesunate alone or with mefloquine; or Artemether+mefloquine
Overall artemisinins dose: 12–16 mg/kg
Treatment failure at day 42; anaemia; ADR; neurological deficit
Birth outcome; infant neurological development
TBB, 1991–1996 [18] Pregnant women with uncomplicated multi-drug resistant P. falciparum malarial infection after treatment failure
Trimesters (n): 3rd & 2nd (74), 1st (16)
Artesunate alone or with mefloquine; or Artemether+mefloquine
Overall artemisinins dose: 12–16 mg/kg
Treatment failure at day 42; anaemia; ADR; neurological deficit
Birth outcome; infant neurological development
TBB, 1992–2000 [16] Pregnant women with uncomplicated multi-drug resistant P. falciparum or mixed malarial infection
Trimesters (n): 3rd (211), 2nd (201), 1st (42)
Artesunate alone or with mefloquine; clindamycin atovaquone-proguanil;or coartemether, artemether IM
Overall artemisinins dose: 12–16 mg/kg
Treatment failure at day 42; anaemia; ADR; neurological deficit
Birth outcome; infant developmental milestones
TBB 1999–2001 [19] Pregnant women with multi-drug resistant P. falciparum or mixed malarial infection
Trimesters (n): 3rd & 2nd (24), 1st (3)
Artesunate+atovaquone-proguanil
Artesunate overall dose: 12–14 mg/kg
Treatment failure at day 42; parasite clearance; AEs
Birth outcomes
TBB 2000–2001 [20] Pharmacokinetic study: pregnant women with multi-drug resistant P. falciparum or mixed malarial infection
Trimesters (n): 3rd (13) & 2nd (11)
Artesunate+atovaquone-proguanil
Artesunate overall dose: 12 mg/kg
Pharmacokinetic parameters; AEs (including ECG); parasite clearance
Birth outcomes
Gambia, 1999 [41] Pregnant women participating in mass prevention campaign
Trimesters (n): 1st (77)
Artesunate + SP
Artesunate overall dose: 200 mg
MDA 1° aim: malaria transmission
Pregnancy outcomes
Sudan, 1997–2001 [22] Pregnant women infected with P. falciparum malaria after treatment failure§
Trimesters (n): 3rd (15), 2nd (12), 1st (1)
Artemether IM
Artemether overall dose: 480 mg
Treatment failure at day 28; anaemia; neurological deficit
Birth outcomes
Sudan, 2004–2005 [23] Pregnant women infected with uncomplicated P. falciparum malaria§
Trimesters (n): 3rd (22), 2nd (10)
Artesunate + SP
Artesunate overall dose: 200 mg
Treatment failure at day 28; anaemia
Birth outcomes
  1. * 2nd and 3rd trimesters only
  2. §100% symptomatic/febrile
  3. Abbreviation: ADR: adverse drug reaction; AE: adverse event; ECG: electrocardiograph; IM: intramuscular injection; NR: not reported; Q: quinine; A: artemisinin derivative; A+M: artesunate+mefloquine; TBB: Thai-Burmese border