Table 2 Effects of IPT-SP, pyrimethamine or no chemoprophylactic agent on malaria parasitaemia and pregnancy outcomes in parturient women in southwestern Nigeria
Outcome measure | IPT-SP | Pyrimethamine | No Chemoprophylaxis | P value |
|---|---|---|---|---|
N = 598 | N = 214 | N = 171 | ||
n (%) | n (%) | n (%) | ||
Maternal parasitemia | 62 (10.4%) | 34 (15.9) | 29 (17.0) | 0.021 |
Placental parasitemia | 63 (10.5%) | 36 (16.8) | 29 (17.0) | 0.015 |
Cord parasitemia | 16 (2.7%) | 9 (4.2) | 9 (5.3) | 0.210 |
Neonatal parasitemia | 4 (0.7%) | 3 (1.4) | 1 (0.6) | 0.553 |
Maternal haematocrit(%) | ||||
Mean ± SD | 36.48 ± 4.55 | 36. 39 ± 4.7 | 35.17 ± 5.58 | 0.006 |
Range | 18 – 45 | 20 – 45 | 17 – 45 | |
Maternal anaemia | ||||
(Haematocrit <30%) | 33/579 (5.7%) | 19 (8.9) | 26 (15.4) | <0.0001 |
Pre-term delivery | ||||
(Gestational age <37 weeks) | 63 (10.5%) | 41 (19.2) | 43 (25.3) | <0.0001 |
Neonatal birth weight(gm) | ||||
Mean ± SD | 3204.3 ± 487.2 | 3075.7 ± 513.24 | 3074.7 ± 505.9 | <0.0001 |
Range | 1500 – 4700 | 1300 – 4500 | 1400 – 4500 | |
Low birth weight(%) | 31/595 (5.2) | 17 (7.9) | 16 (9.4) | 0.095 |
Neonatal haematocrit(%) | ||||
Mean ± SD | 58.2 ± 7.8 | 57.1 ± 7.66 | 56.8 ± 8.0 | 0.041 |
Range | 35 – 79 | 34 – 75 | 31 – 75 | |
Placental weight(gm) | ||||
Mean 605.54 ± SD | 605.5 ± 113.6 | 607.7 ± 131.9 | 588.9 ± 136. | 0.253 |