Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Table 2 Association of total IgG and IgM with malaria incidence

IgG	Crude IRR (95%CI)	P-value	IRR adjusted for age (95%CI)	P-value
MSP3	0.59 (0.45, 0.76)	< 0.0001	0.69 (0.53, 0.90)	0.01
MSP1₁₉	0.74 (0.63, 0.88)	< 0.0001	0.75 (0.61, 0.92)	0.01
GLURP	0.68 (0.55, 0.82)	< 0.0001	0.79 (0.64, 0.98)	0.04
AMA1	0.96 (0.84, 1.09)	0.50	1.03 (0.89, 1.20)	0.67
IgM:
MSP3	0.62 (0.49, 0.80)	< 0.0001	0.76 (0.59, 0.97)	0.03
MSP1	0.59 (0.47, 0.75)	< 0.0001	0.68 (0.53, 0.88)	< 0.01
GLURP	0.71 (0.58, 0.87)	< 0.01	0.84 (0.68, 1.03)	0.09
AMA1	0.48 (0.34, 0.67)	< 0.0001	0.63 (0.44, 0.91)	0.01

Malaria incidence rate ratios (IRR) with 95% confidence interval, corresponding to a doubling of baseline antibody level, before and after adjustment for the effect of age.

ISSN: 1475-2875