Table 3 Clinical and parasitological responses to treatment with artemether-lumefantrine by body weight group
Body weight group | ||||
|---|---|---|---|---|
Characteristic | BWG1 5-<10 kg | BWG2 10-<15 kg | BWG3 15-<25 kg | Total 5-<25 kg |
Cure rates ITT %(n/M)1 (uncorrected) | N = 50 | N = 37 | N = 16 | N = 103 |
Day 7 | 98.0% (49/50) | 97.3% (36/37) | 100.0% (16/16) | 98.1% (101/103) |
Day 14 | 96.0% (48/50) | 94.6% (35/37) | 93.8% (15/16) | 95.1% (98/103) |
Day 28 | 92.0% (46/50) | 89.2% (33/37) | 93.8% (15/16) | 91.3% (94/103) |
95% CI | (80.8–97.8) | (74.6–97.0) | (69.8–99.8) | (84.1–95.9) |
Day 28 (PCR corrected) | 96.0% (48/50) | 94.6% (35/37) | 93.8% (15/16) | 95.1% (98/103) |
95% CI | (86.3–99.5) | (81.8–99.3) | (69.8–99.8) | (89.0–98.4) |
Cure rate PP %(n/M)1 (uncorrected) | N = 45 | N = 34 | N = 14 | N = 93 |
Day 7 | 100% (45/45) | 100% (34/34) | 100% (14/14) | 100% (93/93) |
Day 14 | 100% (45/45) | 100% (34/34) | 100% (13/13) | 100% (92/92) |
Day 28 | 95.6% (43/45) | 94.1% (32/34) | 100% (13/13) | 95.7% (88/92) |
95% CI | (84.9–99.5) | (80.3 – 99.3) | (-) | (89.2 – 98.8) |
PCT (h) ITT | N = 50 | N = 37 | N = 16 | N = 103 |
Mean ± SE | 24.8 ± 1.3 | 26.2 ± 2.31 | 21.2 ± 4.33 | 24.9 ± 1.28 |
Range | 5.3 – 47.8 | 7.7 – 59.9 | 7.2 – 71.1 | 5.3–71.1 |
Median | 23.8 | 23.8 | 23.0 | 23.8 |
95%CI2 | (23.7–23.9) | (23.1–35.3) | (7.9–23.8) | (23.7–23.8) |
FCT (h) ITT) | N = 50 | N = 37 | N = 16 | N = 103 |
Mean ± SE | 24.5 ± 3.81 | 17.6 ± 2.04 | 44.2 ± 19.98 | 26.1 ± 4.14 |
Range | 3.5 – 163.8 | 4.1 – 47.5 | 7.2–308.7 | 3.5–308.7 |
Median | 23.4 | 8.2 | 15.4 | 22.4 |
(95% CI)2 | (7.8–23.8) | (7.8–23.4) | (7.8–34.6) | (7.9–23.5) |