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Table 1 Pfcrt, pfdhfr and pfdhps haplotypes of P. falciparum parasites from Paragominas (PRG) and Porto Velho (PV), Brazilian Amazon.

From: Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area

Gene

Haplotypes

n (Locality)

%

Mutated codons

pfcrt

S VMNT

63 (18 PRG and 45 PV)

97

2

 

CVMNK

1 (PRG)

1.5

0

 

C/S VMNT

1 (PV)

1.5

1 or 2

pfdhfr

ARI CN VI

27 (14 PRG and 13 PV)

52

3

 

ACI CN VI

3 (1 PRG and 2 PV)

6

2

 

ACI CN VL

17 (1 PRG and 16 PV)

33

3

 

ACNRN VI

1 (PV)

2

2

 

ACIRN VI

1 (PV)

2

3

 

ACNCN VI

1 (PRG)

2

1

 

ACNCSVI

1 (PRG)

2

0

 

ARI CN V I/L

1 (PRG)

2

3 or 4

pfdhps

SGEG A

41 (17 PRG and 24 PV)

65

3

 

SGE AA

9 (1 PRG and 8 PV)

14

2

 

SG KAA

10 (PV)

16

1

 

SGE A/G A

1 (PRG)

1.5

2 or 3

 

SG E/K AA

1 (PV)

1.5

1 or 2

 

SG E/K A/G A

1 (PV)

1.5

1, 2 or 3

  1. Codon positions: pfcrt 72 to 76 (n = 65); pfdhfr 16, 50, 51, 59, 108, 140 and 164 (n = 52); and pfdhps 436, 437, 540, 581 and 613 (n = 63). The sensitive haplotypes are shown in bold characters and the mutated codons are underlined.