From: Population pharmacokinetics of artesunate and amodiaquine in African children
Parameter | Estimate (SE) | Inter-subject variation CV% |
---|---|---|
Ka (h-1) | 0.13 (fixed) | Â |
CL/F (L kg-1 h-1) | 0.610 (0.038) | 22.7% |
Q (L kg-1 h-1) | 0.680 (0.306) | Â |
Vcentral/F (L kg-1) | 35.4 (11.5) | Â |
Vperipheral/F (L kg-1) | 87.9 (17.1) | Â |
T 1/2 (days) | 9.0 [7.3–11.6]1 |  |
σ | 0.457 |  |