The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia

Table 4 Risk of Recrudescence due to Low Antibody Levels to Blood Stage Malarial Antigens in Total Population (N = 268)

Parasite Isolate/Antigen	Odds Ratio*	95% CI	P value
VSA E8B	0.68	0.50-0.94	0.02
VSA A4	0.61	0.40-0.92	0.02
VSA HCD6	0.28	0.08-0.96	0.04
AMA-1	1	0.58-1.75	0.98
MSP2 type 3D7	1.08	0.57-2.07	0.81
MSP2 type FC27	1.08	0.57-2.07	0.81

* All results of antibodies to Variant Surface Antigens were adjusted for CD4 count on day 0 in a multivariate logistic regression model. Additional risk factors for recrudescence were high parasite density (AOR:2.64; P = 0.04), anemia (AOR:4.67; P = 0.0001) and SP treatment (AOR:7.98; P = 0.001).

ISSN: 1475-2875