Table 2 Classification of 35 patients with fatal outcome from cardiac origin presumably related to halofantrine (HF) according to the number of predisposing factors to cardiac complication and indication for halofantrine
From: Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base
Number of predisposing factor(s), number of patients (number of children) | Details on predisposing factors (underlying cardiac disease, concomitant medication, misuse of HF, etc) | Wrong or debatable indication for HF |
|---|---|---|
no predisposing factors, n = 9 (0) | Pt # 2, 11§ 12, 16, 17, 18, 20, 31, 33 | a* = 1, b* = 2, c* = 1, d* = 2 |
1 predisposing factor, n = 16 (2) | Pt # 1, 30: vibramycine | b* = 3, c* = 2 |
| Â | Pt # 5, 8, 14, 19: chloroquine | e* = 1 |
|  | Pt # 7: bundle branch block¤ |  |
| Â | Pt # 9, 34: HF taken with food | Â |
| Â | Pt # 13: metronidazole | Â |
| Â | Pt # 21: potassium infusion | Â |
| Â | Pt # 23: unknown severe cardiac valve disease | Â |
| Â | Pt # 24: angina pectoris | Â |
| Â | Pt # 25: ciprofloxacine | Â |
| Â | Pt # 29: mefloquine | Â |
| Â | Pt # 32: HF overdose (45 mg/kg) | Â |
2 predisposing factors, n = 5 (2) | Pt # 3: cardiomyopathy¤ + furosemide | a* = 1; c* = 1 |
| Â | Pt # 4: obesity + chloroquine | d* = 1; f* = 1 |
| Â | Pt # 6: tachycardia + mefloquine | Â |
| Â | Pt # 10: severe anaemia and dehydration + amodiaquine | Â |
| Â | Pt # 26: unknown right ventricular arrhythmogenic dysplasia + chloroquine | Â |
3 predisposing factors, n = 5 (1) | Pt # 15: cardiac arrhythmia + chloroquine + amodiaquine | b*= 2; c* = 2 |
| Â | Pt # 22: arteriosclerosis and high blood pressure + indapamide + HF taken with food | Â |
| Â | Pt # 27: unknown cardiomyopathy + mefloquine + erythromycin | Â |
|  | Pt # 28: unknown right ventricular arrhythmogenic dysplasia + chloroquine + probable HF overdose° |  |
|  | Pt # 35: tachyarrhythmia¤ + mefloquine + HF overdose (72 mg/kg) |  |