| Lariam (n = 12) | Mephaquin (n = 12) | Mefloquina AC (n = 13) | All (n = 37) |
---|---|---|---|---|
C max (ng/ml) | 2820 (2614–3108) | 2500 (2363–2713)* | 2750 (2550–3000) | 2700 (2500–3000) |
AUC 0→t (mg/ml/day) | 59.7 (41–67) | 56.1 (51–60) | 50.6 (41–67) | 56.9 (44–66) |
AUC ∟ (mg/ml/day) | 63.59 (43–77) | 62.32 (60–68) | 59.42 (47–71) | 62.37 (47–75) |
t max (hours) | 45 (41–58) | 51.5 (38–66) | 45 (36–54) | 45 (36–57) |
t 1/2 (hours) | 346 (315–368) | 365 (342–449) | 347 (289–365) | 347 (315–408) |
V d/f (L/kg) | 7.87 (7.0–10.8) | 9.03 (8.16–9.83) | 8.34 (7.0–11.0) | 8.57 (7.3–10.7) |
C l/f (L/h/kg) | 0.016 (0.014–0.024) | 0.017 (0.016–0.018) | 0.018 (0.015–0.022) | 0.017 (0.013–0.022) |