Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection

Table 2 Relationship between subjects' age, titre of anti-MSP1 antibodies, inhibition of binding of specific monoclonal antibodies and multiplicity of infection.

Age (years)	Total Number of Subjects	^aAntibodies to rMSP1		^bmAb12.10	mAb12.8	^cInfection
		Responders (%)	Mean Log titre	H (%)	H (%)	M	S	MOI
<1	38	23 (61)	2.21	7 (18)	8 (21)	14	23	1.5
1 - 5	24	20 (83)	2.35	2 (8)	7 (29)	12	11	1.8
6 - 15	36	34 (94)	2.69	33 (92)	13 (36)	27	8	2.2
>15	49	48 (98)	2.94	15 (31)	18 (37)	20	28	1.5
Total	147	125 (85)	2.60	57 (39)	46 (31)	73	70	1.7

^aAntibodies to rMSP1: Responders is the number of subjects with antibodies against recombinant MSP1,(%) is the percentage of the total.
^bmAb12.10 and mAb 12.8: H refers to the number of individuals with antibodies highly competitive with the mAb; (%) is the percentage of the total.
^cInfection: M refers to individuals with two or more parasite clones; S refers to individuals with only one parasite type detected. MOI is the mean multiplicity of infection based on MSP1 block 2 alleles.

ISSN: 1475-2875