An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours)

Table 4 Haematological and biochemical parameters (ITT)

	Drug type	Day 0	Day 7	Day 14
Total bilirubin
Mean ± SD	AS + SMP	0.58 ± 0.28	0.58 ± 0.28	0.53 ± 0.27
	AS + AQ	0.62 ± 0.27	0.59 ± 0.26	0.53 ± 0.27
p-value		0.191	0.718	0.982
PCV*
Mean ± SD	AS + SMP	29.79 ± 5.18	30.69 ± 4.50	33.65 ± 4.07
	AS + AQ	29.94 ± 5.09	31.78 ± 4.39	34.96 ± 4.32
p-value		0.748	0.008	0.001
AST*
Mean ± SD	AS + SMP	38.76 ± 14.66	37.79 ± 15.59	36.90 ± 13.71
	AS + AQ	38.88 ± 15.54	36.82 ± 15.26	36.41 ± 13.85
p-value		0.929	0.492	0.700
ALT*
Mean ± SD	AS + SMP	31.10 ± 16.63	31.27 ± 15.50	29.93 ± 15.38
	AS + AQ	30.27 ± 15.29	30.04 ± 14.43	29.09 ± 14.68
p-value		0.559	0.365	0.545
CRT*
Mean ± SD	AS + SMP	0.56 ± 0.26	0.55 ± 0.28	0.54 ± 0.27
	AS + AQ	0.55 ± 0.24	0.55 ± 0.25	0.53 ± 0.24
p-value		0.860	0.810	0.745

• PCV = packed cell volume; AST = aspartate aminotransferase; ALT = alanine aminotransferase;
• CRT = creatinine

ISSN: 1475-2875