Table 2 In vitro anti-malarial activities (IC 50 and IC 90 ) of 10 anti-malaria compounds against the P. falciparum 7G8 cell bank parasites
Compound | Maximal concentration tested (nM) | IC 50 (nM) | IC 90 (nM) | ||
|---|---|---|---|---|---|
Average (n = 2) | Standard deviation (n = 2) | Average (n = 2) | Standard deviation (n = 2) | ||
Artemether | 50 | 5.5 | 2.5 | 9.4 | 4.3 |
Artesunate | 50 | 2.5 | 0.3 | 4.6 | 0.9 |
DHA | 50 | 2.6 | 0.7 | 6.2 | 1.9 |
Atovaquone | 400 | 2.1 | 0.3 | 5.5 | 0.3 |
Mefloquine | 200 | 11.9 | 0.5 | 27.3 | 0.5 |
Piperaquine | 200 | 46 | 9 | 68 | 3 |
Lumefantrine | 200 | 34 | 4 | 99 | 13 |
Chloroquine | 1,000 | 130 | 6 | 208 | 8 |
Pyrimethamine | 5,000 | 2,799 | 52 | 4,080 | 248 |
Proguanil | 200,000 | 5,677 | 617 | 18,840 | 5416 |