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Table 5 Combinations of the (GT)n repeat and A(−413)T genotypes

From: Polymorphisms in the Haem Oxygenase-1 promoter are not associated with severity of Plasmodium falciparum malaria in Ghanaian children

(GT)n

T(−413)A

N (%)

OR (95% CI)

P value

SS

AA

0 (0.0)

-

-

SS

AT

3 (0.6)

1.77 (0.15-21.34)

0.65

SS

TT

23 (4.3)

0.63 (0.22-1.84)

0.40

SM

AA

3 (0.6)

<0.001 (<0.001- > 999.99)

1.0

SM

AT

54 (10.0)

1.01 (0.46-2.22)

1.0

SM

TT

22 (4.1)

1.12 (0.42-3.37)

0.75

SL

AA

2 (0.4)

<0.001 (<0.001- > 999.99)

1.0

SL

AT

21 (3.9)

0.39 (0.09-1.58)

0.19

SL

TT

65 (12.1)

0.70 (0.33-1.50)

0.36

MM

AA

37 (6.9)

0.66 (0.27-1.58)

0.35

MM

AT

27 (5.0)

0.70 (0.24-2.04)

0.52

MM

TT

18 (3.4)

0.59 (0.14-2.45)

0.47

ML

AA

9 (1.7)

1.43 (0.28-7.21)

0.66

ML

AT

90 (16.7)

1.30 (0.66-2.57)

0.45

ML

TT

57 (10.6)

0.71 (0.31-1.62)

0.42

LL

AA

2 (0.4)

<0.001 (<0.001- > 999.99)

0.99

LL

AT

25 (4.7)

0.13 (0.02-1.08)

0.06

LL

TT

80 (14.9)

Reference

-

  1. Frequencies of the T(−413)A genotypes combined with the genotypes of the (GT)n repeats. The combinations ML/AT, LL/TT, SL/TT, ML/TT, SM/AT were the most prevalent. No significant association with severity of malaria was found by analysis with logistic regression models, adjusted for age and sex. Significance level p < 0.05.