Table 4 The pharmacokinetic parameters of LUME and 97–78 in rats (n = 5 each)

AUC _0-t (h*μg/mL)

16.52 ± 2.96

9.10 ± 1.48

10.64 ± 0.71^*

8.04 ± 1.26

AUC _0-∞ (h*μg/mL)

17.42 ± 3.29

9.15 ± 1.46

11.02 ± 0.66^*

8.15 ± 1.26

C _max (μg/mL)

1.81 ± 0.75

1.35 ± 0.17

1.92 ± 0.62

1.79 ± 0.69

T _max (h)

3.75 ± 1.50

2.2 ± 1.09

4 ± 2.45

0.5^#

V _d /F (L/kg)

39.45 ± 6.26

106.05 ± 30.57

62.73 ± 8.40^*

142.03 ± 28.13

CL/F (L/h/kg)

0.59 ± 0.09

7.81 ± 1.26

0.91 ± 0.06 ^*

8.76 ± 1.38

t _1/2 (h)

46.94 ± 6.52

9.27 ± 1.33

47.82 ± 6.48

11.25 ± 1.45

RB%

--

--

64.41^*

88.35