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Table 1 Number of AEs or laboratory abnormalities by grade and group in the pre-erythrocytic phase: between day of injection (day 0) and day 5

From: Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

Severity grade

Challenge group (n = 6 per group)

Total

Group 1

2,500 PfSPZ 10 µL × 2 IM

Group 2

2,500 PfSPZ 50 µL × 2 IM

Group 3

2,500 PfSPZ 250 µL × 2 IM

Group 4

3,200 PfSPZ 500 µL × 1 DVI

Group 5

25,000 PfSPZ 10 µL × 2 IM

Group 6

75,000 PfSPZ 10 µL × 2 IM

Grade 1

2

7

5

7

6

2

29

Grade 2

4

1

1

1

2

2

11

Total

6

8

6

8

8

4

40

  1. No grade 3 adverse events were registered during this period.
  2. PfSPZ Plasmodium falciparum sporozoite, IM intramuscular injection, DVI direct venous inoculation.
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Malaria Journal

ISSN: 1475-2875

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