A simple, high-throughput, colourimetric, field applicable loop-mediated isothermal amplification (HtLAMP) assay for malaria elimination

Table 5 Comparison of sensitivity and specificity of HtLAMP-Pg and HtLAMP-Pf for the detection of P. falciparum and non-falciparum species with other LAMP studies in symptomatic patients

LAMP study	Sample source	Species	LAMP primer	Sensitivity (%)	Specificity (%)
HtLAMP	Symptomatic patients	P. falciparum	Pg	98	83
HtLAMP	Symptomatic patients	P. falciparum	Pf	97	96
Polley et al. [23]	Symptomatic patients	P. falciparum	Pg	93.9	100
Polley et al. [23]	Symptomatic patients	P. falciparum	Pf	93.3	100
Polley et al. [27]	Symptomatic returned travellers	P. falciparum	Pg	97	99.2
Polley et al. [27]	Symptomatic returned travellers	P. falciparum	Pf	98.4	98.1
Hopkins et al. [30]	Passive case detection	P. falciparum	Pf	89–93.9	76.3–85
HtLAMP	Symptomatic patients	Non-falciparum	Pg	100	83
Vallejo et al. [32]	Symptomatic patients	Non-falciparum	Pg	91.4	91.8

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