Table 1 Infectivity of P. falciparum Gametocytes to A. stephensi Mosquitoes in the presence of different pooled bleed sera from mice and rats immunized with R0.10C formulated with different adjuvants in the Standard Membrane-Feeding Assay (SMFA)
Day | Mice | Rats | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Freunds | Alum/GLA | SE/GLA | AbISCO | Alum | Alum/GLA | SE/GLA | AbISCO | |||||||||
Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | Inf | TRA, % | |
0 | 18 | Â | 18 | Â | 19 | Â | 18 | Â | 16 | Â | 17 | Â | 19 | Â | 16 | Â |
14 | 17 | 0 | 11 | 35 | 11 | 26 | 18 | 0 | 20 | 11 | 17 | 2 | 20 | 0 | 17 | 0 |
28 | 7 | 76 | 1 | 97 | 10 | 59 | 4 | 96 | 5 | 94 | 3 | 97 | 10 | 85 | 6 | 91 |
42 | 0 | 100 | 2 | 95 | 1 | 99 | 1 | 99 | 1 | 98 | 1 | 99 | 1 | 99 | 1 | 99 |