Summary of anti-malarial prophylactic efficacy of tafenoquine from three placebo-controlled studies of residents of malaria-endemic countries

Table 10 Protective efficacy based on mITT using a fixed effect model (meta analysis)

Studies pooled	Treatment	PE^a	95 % CI lower limit	95 % CI upper limit
030 and 045	Placebo
030 and 045	Tafenoquine 200-mg weekly	94.1	89.7	96.6
030, 043 and 045	Placebo
030, 043 and 045	Tafenoquine 200-mg weekly	93.4	89.6	95.8

CI confidence interval, mITT modified intent-to-treat
^aCombined estimate of PE (and CI) are based on the fixed effect model of DerSimonian and Laird [13]

ISSN: 1475-2875