Malaria Journal

Table 1 Clinical trials of azithromycin plus other drug against P. falciparum malaria

From: Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria

Study demographic details					Regimen								Efficacy ( %) d28
Year	Place	Reference	Pop	Nb	Azithromycin			Other Drug			Route	Days
Year	Place	Reference	Pop	Nb	Dosage/d	Route	Nb doses/d	Drug^a	Dosage/d	Nb doses/d	Route	Days
1996	Thailand	NaBangchang [78]	A	30	500 mg	PO	1	Ath	300 mg	1	PO	3/1	14.8
2001	India	Dunne 2005 [3]	A	64	1000 mg	PO	2	C	600 mg	2	PO	3	90
2006	Thailand	Noedl 2006 [41]	A	27	1500 mg	PO	2	A	200 mg	2	PO	3	92
			A	27	1000 mg	PO	1	A	200 mg	1	PO	3	89
			A	16	1500 mg	PO	2	Q	20 mg/kg	2	PO	3	73
			A	27	1500 mg	PO	3	Q	30 mg/kg	3	PO	3	92
2006	Thailand	Miller 2006 [44]	A	10	1000 mg	PO	2	Q	30 mg/kg	3	PO	3	90
			A	20	1000 mg	PO	2	Q	30 mg/kg	3	PO	5	100
			A	20	1500 mg	PO	3	Q	30 mg/kg	3	PO	3	100
2007	Malawi	Kalilani 2007 [8]	P	47	1000 mg	PO	2	SP	1500/75 mg	3	PO	2	91
2008	Tanzania	Sykes 2009 [9]	C	129	20 mg/kg	PO	1	A	4 mg/kg	1	PO	3	42
2009	Bangladesh	Thriemer 2010 [43]	A		1500 mg	PO	1	A	200 mg	1	PO	3	95
			or	152	or				or
			C		30 mg/kg	PO	1	A	4 mg/kg	1	PO	3	95
2007–8	Malawi	Laufer 2012 [10]	C	160	30 mg/kg	PO	1	C	10 mg/kg	1	PO	2	99
2004–6	Africa	Sagara 2014 [11]	A	227	1000 mg	PO	1	C	600 mg	1	PO	3	99

Randomized controlled trial
Only trials with adequate dosing, i.e. clindamycin given at least twice daily are mentioned in this table
Pop population, A adult, C children, P pregnant women
^a A artesunate, Ath arthemeter, C chloroquine, F fosmidomycin, Q quinine, SP sulfadoxine–pyriméthamine

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ISSN: 1475-2875

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