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Table 1 Characteristics of Burkina Faso and Ghana study populations

From: Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas

Characteristics

Burkina Faso

Ghana

N

Cumulative incidence (95 % CI)a

Child-months at risk

Malaria cases

Rate per 100 child-months (95 % CI)b

N

Cumulative incidence (95 %CI)a

Child-months at risk

Malaria cases

Rate per 100 child-months (95 % CI)c

Age group (months)

 6–23

99

83.7 % (75.7, 90.2)

1071.2

191

17.8 (15.9, 19.7)

16

43.8 % (23.8, 70.5)

152.7

7

4.6 (2.2, 9.6)

 24–35

87

82.5 % (73.7, 89.7)

947.0

176

18.6 (16.6, 20.6)

54

5.6 % (1.8, 16.2)

509.8

3

0.6 (0.2, 1.8)

 36–47

90

69.7 % (60, 78.8)

982.0

120

12.2 (10, 14.4)

54

5.6 % (1.8, 16.2)

510.8

3

0.6 (0.2, 1.8)

 48–72

78

42.4 % (32.3, 54.2)

851.0

52

6.1 (3.8, 8.4)

85

5.9 % (2.5, 13.6)

802.1

6

0.7 (0.3, 1.7)

Baseline parasitaemia status

 Negative

132

82.6 % (75.7, 88.5)

1432.9

249

17.4 (15.8, 19)

203

8.9 % (5.7, 13.7)

1919.0

19

1.0 (0.6, 1.6)

 Positive

219

63.8 % (57.4, 70.2)

2386.5

288

12.1 (10.6, 13.6)

6

0 %

0

0

–

GLURP R2 IgG serological status

 Non-responder

230

80 % (74.6, 84.9)

2499.5

404

16.2 (14.9, 17.4)

167

9 % (5.5, 14.5)

1577.0

16

1.0 (0.6, 1.7)

 Responder

124

52.6 % (44, 61.7)

1351.7

135

10 (7.9, 12.1)

42

7 % (2.4, 20.5)

398.3

3

0.8 (0.2, 2.3)

MSP1 hybrid IgG serological status

 Non-responder

272

75.1 % (69.8, 80.2)

2953.8

448

15.2 (13.9, 16.4)

166

8.4 % (5.1, 13.8)

1567.7

15

1.0 (0.6, 1.6)

 Responder

82

56.1 % (45.8, 67)

897.4

91

10.1 (7.7, 12.6)

43

9.3 % (3.6, 22.9)

407.6

4

1.0 (0.4, 2.6)

AS202.11 IgG serological status

 Non-responder

313

71 % (65.9, 75.9)

3406.2

486

14.3 (13.1, 15.5)

184

9.2 % (5.9, 14.4)

1738.5

18

1.0 (0.7, 1.6)

 Responder

41

68.1 % (53.4, 81.9)

444.9

53

11.9 (9, 14.8)

25

4 % (0.6, 25.2)

236.8

1

0.4 (0.1, 3.0)

Total

354

70.7 % (65.8, 75.3)

3851.2

539

14 (12.9, 15.1)

209

8.6 % (5.5, 13.3)

1975.3

19

1.0 (0.6, 1.5)

  1. N number of children
  2. aCumulative incidence and 95 % CI was calculated using Kaplan-Meier method
  3. b95 % CI was calculated using the method by Stukel et al., [32]
  4. c95 % CI was calculated using standard method for rate; there was only one multiple episode
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