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Table 3 Prevalence of pfhrp2− in false negative PfHRP-2 RDT test determined by PCR

From: Plasmodium falciparum histidine rich protein-2 diversity and the implications for PfHRP 2: based malaria rapid diagnostic tests in Ghana

 

PfHRP-2 RDT−

PfHRP-2 RDT+

pfhrp2 PCR− (Accra)

23 % (6/26)

36 % (34/94)

pfhrp2 PCR+ (Accra)

77 % (20/26)

64 % (60/94)

pfhrp2 PCR− (Cape Coast)

0 % (0/12)

14 % (1/7)

pfhrp2 PCR+ (Cape Coast)

100 % (12/12)

86 % (6/7)

  1. Samples that were confirmed as P. falciparum positive by PCR genotyping were grouped according to their PfHRP-2 RDT result, PfHRP-2 RDT positive (PfHRP-2 RDT+) or PfHRP-2 RDT negative (PfHRP-2 RDT−). pfhrp2 exon 2 PCR amplification was performed on each sample to estimate effect of the presence of absence of pfhrp2 on malaria diagnosis by PfHRP-2 RDT kits