Table 1 Objection function values, parameter estimates and their precision for the final covariate model and the bootstrap. The bootstrap estimates are derived from the final covariate model

Pharmacokinetic parameter^a

 MTT (h)

0.773 (43.1)

 CL_CQ/F (L/h)

6.13 (3.40)

 V_{C CQ}/F (L)

468 (16.0)

 V_{P CQ}/F (L)

1600 (5.21)

 Q_CQ/F (L/h)

37.7 (18.9)

 t_1/2 CQ (days)

10.7

 CL_DCQ/F (L/h)

2.04 (3.50)

 V_{C DCQ}/F (L)

2.27 (14.1)

 V_{P DCQ}/F (L)

566,257 (14.4)

 Q_DCQ/F (L/h)

31.46 (12.3)

 t_1/2 DCQ (days)

8.74

Interindividual variability^b

 BSV V_{C DCQ}

48.7 (47.5)

 BSV V_{P CQ}

20.0 (61.6)

 BSV V_{P DCQ}

86.8 (30.5)

 BSV F

19.4 (31.7)

Residual variability^c

 Proportional error CQ

0.401 (5.34)

 Proporional error DCQ

0.431 (4.97)