Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Table 1 The initial status of the monkeys and in vivo pharmacodynamics, parasites clearance values

Parameters	Unit	Rx	Median	25th IQT	75th IQT	p^a
Monkey age	Year	IV AL	8	8	10	1.0
Monkey age	Year	IV AS	9	7	12	1.0
Monkey weight	kg	IV AL	8.4	6.7	9.0	0.8
Monkey weight	kg	IV AS	7.7	6.9	8.7	0.8
Parasite density^b	Count mL⁻¹	IV AL	727,850	639,946	848,916	<0.001
Parasite density^b	Count mL⁻¹	IV AS	261,452	139,771	489,064	<0.001
Parasites/erythrocyte (PE)	%	IV AL	12.0	11.3	12.7	<0.001
Parasites/erythrocyte (PE)	%	IV AS	6.60	4.23	6.83	<0.001
Parasites clearance rate (PCR)	Count min⁻¹	IV AL	5.34	4.32	6.54	0.1
Parasites clearance rate (PCR)	Count min⁻¹	IV AS	4.13	3.69	5.28	0.1
Parasites clearance half-life (PCt_1/2)	Hr	IV AL	7.79	6.36	9.63	0.1
Parasites clearance half-life (PCt_1/2)	Hr	IV AS	10.1	7.88	11.3	0.1
95 % Parasites clearance (PC95)	Day	IV AL	1.22	1.13	1.27	0.01
95 % Parasites clearance (PC95)	Day	IV AS	0.847	0.557	1.03	0.01
99 % Parasites clearance (PC99)	Day	IV AL	2.03	1.89	2.08	0.3
99 % Parasites clearance (PC99)	Day	IV AS	1.84	1.47	2.01	0.3
Parasites clearance (PCT)^c	Day	IV AL	None	None	None	NA
Parasites clearance (PCT)^c	Day	IV AS	7.00	5.07	8.00	NA

ISSN: 1475-2875